Dissecting the Roles of Innate Cells in the Skin and Intractable Skin Diseases
January 2022
in “
The Keio Journal of Medicine
”
Studysummary This research describes how hair follicles regulate skin immune cells and how disruption in certain signaling pathways can lead to skin dysbiosis and inflammation; it also highlights the role of macrophages in protecting against cellulitis in mice. Our plain-language summary of this paper — not a Tressless recommendation.
The study explored the role of hair follicles as regulators of immune cells in the skin, highlighting their production of chemokines and cytokines essential for immune cell localization. Disruption of specific signaling pathways, such as the ADAM17-EGF receptor and ADAM10-Notch axes, led to skin dysbiosis, with Staphylococcus aureus causing atopic inflammation and Corynebacterium species leading to hair follicle destruction. The research also examined the hypodermis, finding that macrophage depletion in this layer protected mice against S. aureus-mediated cellulitis. Additionally, the study discussed ongoing research into Degos disease, a rare and fatal condition.
