Search

for
Search:

Research

5 / 1000+ results

research MicroRNA-205 promotes hair regeneration by modulating mechanical properties of hair follicle stem cells

December 2022 in “bioRxiv (Cold Spring Harbor Laboratory)”

This study found that inducing miR-205 reduces actin contractility and stiffness in hair follicle stem cells and progenitors, stimulating hair regeneration in both young and old mice.

research MicroRNA-205 promotes hair regeneration by modulating mechanical properties of hair follicle stem cells

11 citations , May 2023 in “Proceedings of the National Academy of Sciences”

This study found that hair follicle stem cells are stiff with high actomyosin contractility, while hair germ progenitors are soft and enlarge during quiescence, influencing hair regeneration; inducing miR-205 reduces contractility and activates regeneration in mice.

research The incidental pore: Ca_V1.2 and stem cell activation in quiescent hair follicles

3 citations , June 2013 in “Genes & development”

In their research, Yucel and colleagues found that CaV1.2 is expressed in hair follicle stem cells, facilitating anagen re-entry in a way not dependent on calcium flux.

research Transcriptional Governance of Hair Follicle Stem Cell Quiescence and Niche Maintenance in Long-Term Tissue Regeneration

September 2025 in “Digital Commons - RU (Rockefeller University)”

In this study, researchers found that mice lacking the transcription factor FOXC1 in their hair follicle stem cells had increased rounds of hair regeneration but experienced hair thinning due to impaired ability to maintain stem cell quiescence and adhesion.

research 880 Gasdermin A3-mediated cell death causes niche collapse and precocious activation of hair follicle stem cells

2 citations , April 2019 in “Journal of Investigative Dermatology”

This study found that overexpression of Gasdermin A3 in mice disrupts the hair follicle stem cell niche and causes hair loss through cell necrosis and abnormal hair cycle progression, without involving immune-mediated mechanisms.

View more "cell cycle re-entry" in research →

Community Join

5 / 553 results

community Everything you ever wanted to know about Pelage Pharma's PP405: how it works and what to expect

126 upvotes 3 months ago

PP405 may encourage earlier hair growth and slightly increase visible hair count but does not reverse hair follicle miniaturization in male pattern baldness. It does not address damage to the dermal papilla or broken Wnt signaling.

community Tazarotene shows strong standalone hair regrowth potential, not just a Minoxidil enhancer. Backed by VEGF, HF regeneration, and angiogenesis pathways. Here’s why.

135 upvotes 1 year ago

Tazarotene shows potential as a standalone treatment for hair regrowth by stimulating new hair follicle formation and promoting angiogenesis, similar to microneedling effects. It can be used topically without minoxidil, but users should start with a low concentration to avoid irritation.

community Finally, some real breakthroughs. A comparison of the two leading baldness treatments: PP405 versus ABS-201

106 upvotes 11 months ago

PP405 and ABS-201 are promising treatments for male pattern baldness. PP405 shows rapid hair growth in human trials, while ABS-201 shows significant regrowth in animal studies but is still in early human trials.

community The mechanism of androgenic alopecia

36 upvotes 11 months ago

DHT may inhibit hair growth by affecting mitochondrial function, leading to hair follicle miniaturization. Treatments like minoxidil and PP405 may promote hair growth by altering metabolic pathways, potentially counteracting DHT's effects.

community Dutasteride takes 1-3 months to work in the scalp. Not weeks. Be careful.

in Finasteride/Dutasteride 41 upvotes 2 years ago

Dutasteride takes 1-3 months to affect scalp DHT levels, not just a week. The prostate absorbs Dutasteride faster than the scalp due to different vascular networks and enzyme densities.

View more "cell cycle re-entry" in community →

Learn

1 / 20 results

learn Neem Oil

Oil from the neem tree, used in traditional remedies

View more "cell cycle re-entry" in learn →

Experts

2 / 7 results

Clinics

3 / 13 results

Search

for
Search:

Research

research MicroRNA-205 promotes hair regeneration by modulating mechanical properties of hair follicle stem cells

research MicroRNA-205 promotes hair regeneration by modulating mechanical properties of hair follicle stem cells

research The incidental pore: Ca_V1.2 and stem cell activation in quiescent hair follicles

research Transcriptional Governance of Hair Follicle Stem Cell Quiescence and Niche Maintenance in Long-Term Tissue Regeneration

research 880 Gasdermin A3-mediated cell death causes niche collapse and precocious activation of hair follicle stem cells

Community Join

community Everything you ever wanted to know about Pelage Pharma's PP405: how it works and what to expect

community Tazarotene shows strong standalone hair regrowth potential, not just a Minoxidil enhancer. Backed by VEGF, HF regeneration, and angiogenesis pathways. Here’s why.

community Finally, some real breakthroughs. A comparison of the two leading baldness treatments: PP405 versus ABS-201

community The mechanism of androgenic alopecia

community Dutasteride takes 1-3 months to work in the scalp. Not weeks. Be careful.

Learn

learn Neem Oil

Experts

Marcello De Re Camilot

Renuka Saigal

Clinics