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Glossaryp21 (CDK inhibitor 1)

protein that inhibits cell cycle progression for DNA repair

p21 is a protein that acts as a regulator of the cell cycle. It is known for its role in inhibiting the activity of cyclin-dependent kinases (CDKs), which are crucial for cell division. By doing so, p21 can halt the cell cycle, allowing for DNA repair or triggering cell death if the damage is irreparable. This function is particularly important in preventing the proliferation of damaged cells, which can lead to cancer.

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research Activation of the Integrated Stress Response in Human Hair Follicles

June 2024 in “PLoS ONE”

Blocking the Mitochondrial Pyruvate Carrier causes stress in hair follicles, which can be reduced by an ISR inhibitor.

research Preclinical Pharmacology, Antitumor Activity, and Development of Pharmacodynamic Markers for the Novel, Potent AKT Inhibitor CCT128930

65 citations , February 2011 in “Molecular cancer therapeutics”

CCT128930 is a promising new drug that effectively targets and inhibits a cancer-related protein, showing potential for cancer treatment.

research Cell Cycle Regulation and Regeneration

27 citations , January 2012 in “Current Topics in Microbiology and Immunology”

Mice that can regenerate tissue have cells that pause in the cell cycle, which is important for healing, similar to axolotls.

research Transforming Growth Factor-Beta in Stem Cells and Tissue Homeostasis

245 citations , January 2018 in “Bone Research”

TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.

research The Promoting Effect of Ishige Sinicola on Hair Growth

26 citations , May 2013 in “Marine Drugs”

Ishige sinicola, a type of seaweed, may help hair grow by blocking a hair loss-related enzyme and boosting important cell growth.

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