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SRD5A3

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SRD5A3 Is Required for Converting Polyprenol to Dolichol and Is Mutated in a Congenital Glycosylation Disorder

research SRD5A3 Is Required for Converting Polyprenol to Dolichol and Is Mutated in a Congenital Glycosylation Disorder

260 citations , July 2010 in “Cell”

Mutations in the SRD5A3 gene cause a new type of glycosylation disorder by blocking the production of a molecule necessary for protein glycosylation.

Delayed Puberty: Diagnosis and Management of Congenital Idiopathic Hypogonadotropic Hypogonadism

research Delayed Puberty: Diagnosis and Management of Congenital Idiopathic Hypogonadotropic Hypogonadism

January 2016 in “Springer eBooks”

A 19-year-old male with delayed puberty was successfully treated for a condition that prevents normal hormone production.

research ATP6AP1-CDG: Follow-Up and Female Phenotype

7 citations , April 2020 in “JIMD Reports”

ATP6AP1‐CDG can cause hearing loss, hair loss, and protein issues, even in female carriers.

Inhibition of CISD1 Attenuates Cisplatin-Induced Hearing Loss in Mice via the PI3K and MAPK Pathways

research Inhibition of CISD1 Attenuates Cisplatin-Induced Hearing Loss in Mice via the PI3K and MAPK Pathways

May 2024 in “Biochemical pharmacology”

Blocking CISD1 reduces hearing loss from cisplatin in mice.

research Phospholipase Cδ1 Is Required for Skin Stem Cell Lineage Commitment

101 citations , June 2003 in “The EMBO Journal”

Phospholipase Cδ1 is crucial for normal skin and hair development.

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community My Finasteride Story (Pictures + Blood work + Updates)

in Finasteride 8 upvotes 7 years ago

A user shared their experience with finasteride for hair regrowth, which was effective but caused side effects like gynecomastia and mood swings. They now manage side effects with Arimidex and vitamins while continuing finasteride, and monitor their health with blood tests.

community Fin raised my estrogen but also testosterone?

in Finasteride/Dutasteride 17 upvotes 2 years ago

A user experienced initial side effects from finasteride, including erectile dysfunction and emotional changes, but later noticed increased muscle mass and assertiveness. Hormonal tests showed elevated estrogen and prolactin levels, which slightly decreased over time; the user plans lifestyle changes to see if they help.

community Transitioning from fin to RU58841 + Oral Minoxidil - how long until I lose all my fin gains?

in Update 3 upvotes 7 months ago

The user transitioned from finasteride to RU58841 and oral minoxidil to maintain hair gains while avoiding systemic DHT suppression. They have not experienced increased shedding or side effects since stopping finasteride and hope RU58841 will preserve their hair.