Transitioning from fin to RU58841 + Oral Minoxidil - how long until I lose all my fin gains?
    Update 8/8/2025

    From the encyclopedia
    Finasteride →

    Frontline, gold standard treatment for combatting androgenic alopecia

    RU58841 →

    a potent but unapproved and potentially problematic topical anti-androgen

    At a glance
    In this treatment experience post, the primary subjects mentioned are
    💊 Finasteride (oral) 0.5mg daily 1 year 1 month
    💧 RU58841 (topical) 50mg/ml - 1ml dose since May 2025
    💊 Oral Minoxidil (oral) 2.5mg since May 2025
    💧 Ketoconazole shampoo (topical)
    the tone is 😐 neutral with some regrowth results.

    Other terms

    The user transitioned from finasteride to RU58841 and oral minoxidil to maintain hair gains while avoiding systemic DHT suppression. They have not experienced increased shedding or side effects since stopping finasteride and hope RU58841 will preserve their hair.
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    5 / 5 results

      community How to minimize hair loss while waiting to start finasteride (17M)

      in Technology  6 upvotes 5 months ago
      A 17-year-old is using topical minoxidil for hair loss and is considering other treatments like ketoconazole shampoo and saw palmetto while waiting to start finasteride at 19. Suggestions include using oral minoxidil, topical antiandrogens like RU58841, and CB-03-01, with a focus on minimizing systemic DHT impact.

      community Attacking DHT synergistically both locally at the scalp and systemically = Greater Success??

      in Finasteride/Dutasteride  15 upvotes 1 year ago
      The user has been using oral Dutasteride, RU58841, and Minoxidil for three years without success and is considering adding topical Finasteride or Dutasteride to target DHT both locally and systemically. Other users suggest sticking to a consistent treatment plan, exploring different combinations, and considering other factors like potential misdiagnosis or inconsistent medication use.

      community Any treatment not nuking systemic DHT levels?

       16 upvotes 6 months ago
      Hair loss treatments that avoid significantly lowering systemic DHT levels, focusing on topical options like dutasteride mesotherapy, minoxidil, and ketoconazole. The user is exploring alternatives like KX-826 and RU58841 due to concerns about hormone levels.

      community Trying to regrow crown been on Fin for 4.5 years

      in Finasteride/Dutasteride  6 upvotes 2 years ago
      The user has been on finasteride for 4.5 years and minoxidil for 10 years, maintaining hair but not regrowing much on the crown and temples. They are considering using a dermastamp more frequently and possibly trying RU58841, but are hesitant about dutasteride due to concerns about side effects and DHT suppression.

    Related Research

    6 / 6 results
      Alopecia: The Search for Novel Agents Continues

      research Alopecia - the search for novel agents continues

      11 citations , August 1997 in “Expert Opinion on Therapeutic Patents”
      This review discusses nearly 70 patent applications for the treatment of androgenetic alopecia and other hair conditions, highlighting the mechanisms of action explored but reports no clinical results.
      Clinical Updates in Hair

      research CLINICAL UPDATES IN HAIR

      19 citations , January 1997 in “Dermatologic Clinics”
      This chapter reviews various antiandrogens and androgen inhibitors, detailing their mechanisms, uses, and side effects, with a focus on spironolactone, finasteride, dutasteride, and oral contraceptives.
      Antiandrogens and Androgen Inhibitors in Dermatologic Treatments

      research Antiandrogens and Androgen Inhibitors

      November 2020 in “Elsevier eBooks”
      This source outlines various antiandrogen and androgen inhibitor drugs used to treat cutaneous disorders of hyperandrogenism, detailing their mechanisms, uses, dosages, and side effects, with emphasis on spironolactone, finasteride, dutasteride, and oral contraceptives.
      Investigational Medications in the Treatment of Alopecia

      research Investigational medications in the treatment of alopecia

      3 citations , February 2005 in “Expert Opinion on Investigational Drugs”
      This review discusses investigational treatments for androgenetic and chemotherapy-induced alopecia and reports no new clinical results, highlighting the need for further research.