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This study found that overexpression of miR-1246 in peripheral CD4+ T cells can reduce markers associated with inflammation and T cell activation in severe active alopecia areata, suggesting potential therapeutic benefits.

Increased Treg cells and IL-10 may help quick recovery in acute diffuse and total alopecia.

In this animal study, researchers discovered that CD4 T cells from mice with alopecia areata can induce the disease more efficiently than those from unaffected mice, likely by supporting CD8 T cell activation and hair follicle attack.

T cells affect skin cell genes in inflammatory diseases, and therapy can normalize these changes.

People with acne have more CD4+ immune cells in their skin than healthy people.