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GlossaryBRAF Mutation

mutation in the BRAF gene affects cell growth and division

A BRAF mutation refers to a change in the BRAF gene, which plays a crucial role in cell growth and division. This mutation can lead to uncontrolled cell proliferation and is often associated with various cancers, including melanoma, colorectal cancer, and thyroid cancer. The most common BRAF mutation is V600E, where valine (V) is replaced by glutamic acid (E) at position 600 in the protein. This mutation can be a target for specific cancer therapies, making it a significant focus in oncology.

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Lentiginous Melanoma: A Clinically Malignant Entity That Histopathologically Seems Benign. Case Study Harboring BRAF V600R Mutation

research Lentiginous Melanoma: A Clinically Malignant Entity That Histopathologically Seems Benign. Case Study Harboring BRAF V600R Mutation

1 citations, March 2015 in “Journal of the European Academy of Dermatology and Venereology”

A clinically suspected melanoma appeared benign under the microscope but was confirmed by specific tests and a rare mutation.

research Melanoma: Genetic Abnormalities, Tumor Progression, Clonal Evolution, And Tumor-Initiating Cells

37 citations, November 2017 in “Medical Sciences”

Melanoma's complexity requires personalized treatments due to key genetic mutations and tumor-initiating cells.

research Hair and Nail Adverse Events During Treatment with Targeted Therapies for Metastatic Melanoma

32 citations, May 2016 in “European journal of dermatology/EJD. European journal of dermatology”

Targeted therapies for advanced skin cancer often cause hair and nail problems, which need managing to avoid changing the treatment dose.

research A Cross-Sectional Study of Clinical, Dermoscopic, Histopathological, and Molecular Patterns of Scalp Melanoma in Patients With or Without Androgenetic Alopecia

September 2022 in “Scientific Reports”

Scalp melanoma is more common and easier to diagnose early in people with androgenetic alopecia due to sun damage.

research A Cross-Sectional Study of Clinical, Dermoscopic, Histopathological, and Molecular Patterns of Scalp Melanoma in Patients With or Without Androgenetic Alopecia

April 2022

Scalp melanoma is often diagnosed late in people with hair loss, leading to worse outcomes.

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community Huge Group Buy is Now Live with New and Existing Treatments

in Product 146 upvotes 1 year ago

A group buy for hair loss treatments including Harmine 19a, TM5614, Abiraterone Acetate, and others. A compound, BMS-202, that can potentially reverse gray hair is also mentioned.