759 citations
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February 2009 in “Current Biology”
This review summarizes fundamental concepts and recent advancements in hairfollicle biology, including insights from mouse models into broader molecular and cellular processes relevant to regeneration and development.
This study found that human scalp hairfollicles can respond to corticotropin releasing hormone stimulation similarly to the classical HPA axis, including up-regulating cortisol production and activating neuroendocrine feedback loops.
This study found that Shh from neurons signals to Gli1-expressing cells in the hairfollicle, cultivating a niche where these bulge cells can potentially transform into epidermal stem cells in wound healing.
Hairfollicles can be dormant and potentially revived with treatments like finasteride and minoxidil, but irreversible loss occurs if certain structures are destroyed. Early intervention is more effective, and additional methods like microneedling may help.
Scientists have grown natural-looking hair from stem cells, potentially revolutionizing hair growth treatments. Concerns include cost, DHT resistance, and the need for future procedures.
Hairfollicles can experience regrowth with treatments like finasteride, minoxidil, Nizoral, dermarolling, collagen, and biotin, but some may not fully recover. Expectations should be managed as full regrowth to teenage levels may not be possible.
Hair regrowth from treatments like finasteride, dutasteride, and minoxidil can take several years, with most visible results appearing within 1-2 years and potential improvements continuing up to 10 years. Consistency and patience are crucial for achieving maximum hair thickness, as hair miniaturization and regrowth are gradual processes.
Creating new hairfollicles is unlikely in the next 10-20 years, with current treatments focusing on stimulating existing follicles. Experimental treatments like ky19382 are being tested, but reliable solutions are not yet available.
Hair transplantation moves DHT-resistant follicles from a donor area (back and sides of the scalp) into thinning or bald areas. The transplanted hair is generally permanent, though surrounding native hair can keep thinning.