Search

for
Search:

Did you mean Basal Keratinocytes?

Glossary Basal Keratinocytes

cells in the skin's lowest epidermal layer producing keratin

Basal keratinocytes are the cells located in the lowest layer of the epidermis, which is the outermost layer of the skin. These cells are responsible for producing keratin, a protein that helps protect the skin and underlying tissues. They also play a crucial role in skin regeneration by continuously dividing and pushing older cells towards the surface, where they eventually shed.

Related Terms

Research

5 / 1000+ results

research Expression of the Intermediate Filament Keratin Gene,K15,in the Basal Cell Layers of Epithelia and the Hair Follicle

46 citations , November 1998 in “Experimental Cell Research”

This study found that K15 is variably expressed in sheep and mouse hair follicles, with specific patterns suggesting a role in the early stages of keratinocyte differentiation.

A Mouse Model for Conditional Expression of Activated Beta-Catenin in Epidermal Keratinocytes

research A Mouse Model for Conditional Expression of Activated β-Catenin in Epidermal Keratinocytes

1 citations , August 2024 in “Transgenic Research”

In this study, the researchers observed that inducing and then withdrawing β-catenin expression in a bigenic mouse model caused reversible changes in skin morphology, indicating dependence on β-catenin signaling.

research Induction of dark keratinocytes by 12-O-tetradecanoyl-phorbol-13-acetate and mezerein as an indicator of tumor-promoting efficiency

77 citations , January 1980 in “Carcinogenesis”

This study found that TPA was significantly more effective than mezerein in inducing dark basal keratinocytes in mouse skin, which may be important in early tumor promotion stages.

research Epidermal keratinocyte stem cells: their maintenance and regulation

25 citations , December 1992 in “Seminars in cell biology”

This review discusses how epidermal Langerhan's cells and dermal cells may influence keratinocyte environments, potentially aiding in the formation of stem cell niches and cellular variety in the basal layer, without providing novel results.