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The Peptide AC 2 Isolated from Bacillus-Treated Trapa Japonica Fruit Extract Rescues DHT-Treated Human Dermal Papilla Cells and Mediates mTORC1 Signaling for Autophagy and Apoptosis Suppression

research The Peptide AC 2 Isolated from Bacillus-Treated Trapa Japonica Fruit Extract Rescues DHT-Treated Human Dermal Papilla Cells and Mediates mTORC1 Signaling for Autophagy and Apoptosis Suppression

9 citations , November 2019 in “Scientific reports”

The AC 2 peptide from Trapa japonica fruit helps protect hair cells and may treat hair loss.

Botulinum Toxin Type A Alleviates Androgenetic Alopecia by Inhibiting Apoptosis of Dermal Papilla Cells via Targeting Circ_0135062/Mir-506-3p/Bax Axis

research Botulinum Toxin Type A Alleviates Androgenetic Alopecia by Inhibiting Apoptosis of Dermal Papilla Cells via Targeting Circ_0135062/Mir-506-3p/Bax Axis

January 2024 in “Aesthetic Plastic Surgery”

Botox can help prevent hair loss by blocking cell death in scalp cells.

research Angiopoietin-1 Induces Survival and Proliferation of Hair Follicle Dermal Papilla Cells Through Integrin α5β1 Signaling

September 2025 in “Frontiers in Medicine”

Angiopoietin-1 helps hair cells survive and grow, making it a potential treatment for hair loss.

research The Metabolites of Bifidobacterium Longum BB536 Alleviate DHT-Damaged Human Dermal Papilla Cells by Activating WNT/β-Catenin Signaling

August 2024 in “Food Bioscience”

Bifidobacterium longum BB536 metabolites may help treat hair loss by repairing and promoting hair cell growth.

research Re-Densification Effect of Pressure-Injected Peptide-Hyaluronic Acid Combination on Male Androgenic Alopecia

January 2024 in “Journal of Cosmetics, Dermatological Sciences and Applications”

Injecting a peptide-hyaluronic acid mix improved hair growth in men with hair loss and was safe.

View more "bacillus-treated trapa japonica" in research →

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community [Nov 2019] The peptide AC 2 isolated from Bacillus-treated Trapa japonica fruit extract rescues DHT (dihydrotestosterone)-treated human dermal papilla cells and mediates mTORC1 signaling for autophagy and apoptosis suppression

22 upvotes 6 years ago

A peptide from Japanese water chestnut fruit may help with hair loss by suppressing DHT's effect on hair follicle cell death, potentially serving as a finasteride alternative. The treatment's effectiveness and safety in humans remain uncertain.