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Mutations in specific keratin genes cause improper hair structure in mice due to faulty keratin protein assembly.

The document concludes that Syndromes of Severe Insulin Resistance are rare disorders with limited treatment options.

Patients with myotonic dystrophy often have skin problems that suggest early aging and vitamin D issues, and the severity of these problems is linked to their genetic condition and vitamin D levels.

Biotin supplements are unnecessary for most people but may help with certain conditions like biotin deficiency, brittle nails, and some hair loss.

Birt–Hogg–Dubé syndrome is a rare genetic condition causing skin lesions, lung cysts, and a higher chance of kidney cancer.