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This case report describes a rare instance of a giant and atypical proliferating pilomatrixoma on the eyelid, successfully treated with surgical excision, with no recurrence observed after one year, emphasizing the need to excise and histologically evaluate enlarging periocular masses to rule out malignancy.

A man had a non-cancerous, fast-growing skin lump on his arm that was removed with surgery.

In this case report, researchers detailed a giant proliferating pilomatrixoma in a 36-year-old woman, emphasizing the importance of complete excision to prevent recurrence or potential malignant transformation, distinguishing it from malignancies like angiosarcoma or melanoma.

This review synthesizes existing research on eyelid pilomatrixomas, highlighting the challenges in diagnosis and the importance of understanding their presentation and management strategies.

This case study describes a 4-year-old boy whose neck tumor was initially misdiagnosed as scrofuloderma before being correctly identified as a pilomatricoma, underscoring the need to include pilomatricoma in differential diagnoses for persistent skin lesions.