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Glossary Antioxidant Defenses

Antioxidant defenses refer to the body's mechanisms that protect cells from oxidative stress caused by free radicals, which can damage DNA, proteins, and lipids. In the context of hair loss, oxidative stress has been linked to conditions such as androgenetic alopecia and telogen effluvium, where an imbalance between free radicals and antioxidants can lead to hair follicle damage and impaired hair growth. Key distinguishing characteristics of antioxidant defenses include the presence of enzymes like superoxide dismutase and catalase, as well as non-enzymatic antioxidants such as vitamins C and E, which work together to neutralize harmful oxidative agents. Maintaining robust antioxidant defenses is crucial for promoting healthy hair follicles and potentially mitigating hair loss.

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Research

5 / 1000+ results

research Improvement of Antioxidant Defences in Keratinocytes Grown in Physioxia: Comparison of 2D and 3D Models

9 citations , June 2023 in “Oxidative Medicine and Cellular Longevity”

This study reports that keratinocytes grown under low oxygen conditions (physioxia) demonstrated reduced reactive oxygen species production and increased antioxidant enzyme activity compared to those in higher oxygen conditions, highlighting the role of oxygen in regulating skin antioxidant defenses.

Nobiletin-Loaded Composite Penetration Enhancer Vesicles Restore Normal miRNA Expression and Chief Defense Antioxidant Levels in Skin Cancer

research Nobiletin-loaded composite penetration enhancer vesicles restore the normal miRNA expression and the chief defence antioxidant levels in skin cancer

34 citations , October 2021 in “Scientific Reports”

This study found that nobiletin-loaded vesicles effectively restored skin condition in a mouse model of skin cancer, suggesting they are a promising treatment delivery system.

research Mechanisms and applications of the anti-inflammatory effects of photobiomodulation

520 citations , January 2017 in “AIMS biophysics”

This review discusses the effects of photobiomodulation, particularly its potential to reduce inflammation in various conditions, but it does not report new clinical findings.

research Oxidative stress in ageing of hair

126 citations , January 2009 in “International Journal of Trichology”

This review discusses the potential role of oxidative stress in hair graying and age-related alopecia, emphasizing the need for new strategies to counteract these effects, but reports no new results.

research Selenium or No Selenium- That Is the Question in Tumor Patients: A New Controversy

61 citations , May 2010 in “Integrative Cancer Therapies”

This review discusses the potential benefits and risks of selenium in cancer prevention and treatment, emphasizing that while selenium may offer advantages for tumor patients, further research is needed due to mixed findings regarding diabetes risk.

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Community Join

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community A Study I came along by mistake researching (Dutasteride +Pumpkin seed oil ) for every other day use.

16 upvotes 3 months ago

Alternating Dutasteride with pumpkin seed oil may protect the spleen from damage caused by Dutasteride. Pumpkin seed oil's antioxidants help counteract oxidative stress and immune suppression.

community Best supplements to compliment finasteride protocol

17 upvotes 1 month ago

The conversation discusses supplementing a finasteride regimen for hair loss with Omega 3, Vitamin D/K, Zinc, probiotics, and possibly adding oral minoxidil, magnesium, astaxanthin, and B vitamins. Users suggest testing nutrient levels before adding supplements like zinc and iron, and consider biotin, keratin, and possibly switching to dutasteride or adding topical minoxidil.

community How I recovered from 4+ years of severe balding ages 20-24 by dieting, lifestyle changes and ONLY using topical minoxidil

in Progress Pictures 473 upvotes 1 year ago

A user reversed severe hair loss with dieting, lifestyle changes, and topical minoxidil, highlighting reduced inflammation and body fat. The conversation debates finasteride's effectiveness and the impact of diet and lifestyle on hair health.

community 25 years on Finasteride and it's not working anymore.

324 upvotes 6 months ago

A 47-year-old has been using finasteride for 25 years for hair loss, but it's less effective now. Suggestions include switching to dutasteride, stopping anastrozole, and trying minoxidil, microneedling, and possibly TRT.

community Summary of Procapil video by Haircafe

2 upvotes 1 year ago

Procapil is marketed as a natural hair loss treatment but lacks strong evidence and is industry-biased. Minoxidil and Finasteride are the only FDA-approved treatments for androgenetic alopecia.

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Learn

3 / 801 results

learn Niacinamide

How does Niacinamide support the hair follicle’s nutrition? Niacinamide nourishes hair follicles by boosting energy production and supporting antioxidant defenses.

learn procapil

Could pairing Procapil with antioxidants be the power combo for stress-induced hair thinning? Procapil combined with antioxidants may effectively combat stress-induced hair thinning.

learn horsetail extract

How does horsetail extract support hair growth — is it the silica, the antioxidants, or both? Horsetail extract supports hair growth primarily through its silica content.

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