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Glossary Antiandrogenic

substances inhibit male sex hormones like testosterone

Antiandrogenic refers to substances or treatments that inhibit the effects of androgens, which are male sex hormones like testosterone. These substances can be used to treat conditions like androgenic alopecia (hair loss) and prostate cancer by blocking the action of these hormones, thereby reducing their influence on hair follicles and other tissues.

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Research

5 / 1000+ results

Solubilities of Flutamide, Dutasteride, and Finasteride as Antiandrogenic Agents in Supercritical Carbon Dioxide: Measurement and Correlation

research Solubilities of Flutamide, Dutasteride, and Finasteride as Antiandrogenic Agents, in Supercritical Carbon Dioxide: Measurement and Correlation

19 citations , September 2009 in “Journal of Chemical & Engineering Data”

This study found that the solubilities of flutamide, dutasteride, and finasteride in supercritical carbon dioxide were effectively modeled using semiempirical equations by Chrastil and Bartle, with varying levels of accuracy.

research Herbs as Antiandrogenic Agents

June 2026

This literature review suggests that herbal extracts show promise as antiandrogenic agents for androgen-related conditions, potentially offering a natural alternative with fewer side effects than synthetic medications.

Development and Validation of Androgen-Induced Hair Loss and Anagen Induction Mouse Models for Pharmacological Evaluation of Anti-Androgenic Agents

research Development and Validation of Androgen-induced Hair Loss and Anagen Induction Mouse Models for Pharmacological Evaluation of Anti-Androgenic Agents

1 citations , April 2024 in “Journal of Pharmaceutical and Pharmacological Sciences”

This study evaluated androgen-induced hair loss and anagen induction mouse models, finding that Minoxidil and Pyrilutamide significantly promoted hair growth by decreasing androgen receptor protein levels and enhancing the Wnt/β-Catenin signaling pathway, supporting their use in studying novel treatments for androgenetic alopecia.

research Use of Antiandrogens as Therapeutic Agents in COVID-19 Patients

5 citations , December 2022 in “Viruses”

This review highlights recent insights into using antiandrogens as preventive and therapeutic measures against COVID-19, emphasizing their role in blocking viral infection by modulating androgen-mediated host protease TMPRSS2 and cell entry protein ACE2, with varying success in clinical trials.

research Use of Antiandrogens as Therapeutic Agents in COVID-19 Patients

November 2022

This review summarizes the latest updates on using antiandrogens as potential prophylactic and therapeutic options for COVID-19, highlighting that androgen-mediated regulation of factors like TMPRSS2 and ACE2 is involved in SARS-CoV-2 infection, suggesting a strategy to block viral entry into cells.

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Community Join

5 / 299 results

community Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens.

2 upvotes 1 year ago

A method for treating androgenic alopecia using minoxidil, antiandrogens, exercise, and cold exposure to promote hair growth. Environmental factors and lifestyle changes, like diet and exercise, can improve treatment effectiveness.

community Does ketokonazole on its own improve androgenetic alopecia?

in Ketoconazole 10 upvotes 6 months ago

Ketoconazole can slightly improve hair density and is best used as an adjunct to treatments like finasteride and minoxidil. It helps with scalp health but won't stop androgenetic alopecia on its own.

community Why do I have the feeling that this subreddit is flooded by Kintor employees?

in Chat 132 upvotes 2 years ago

Users discuss aggressive promotion of Koshine 826, suspecting Kintor employees are behind it. Concerns are raised about its effectiveness, with some preferring alternatives like finasteride and minoxidil.

community SCUBE3 and GT20029 could be the closet thing to a cure: Hair Follicle Regeneration and Protection Against DHT

14 upvotes 3 years ago

SCUBE3 and GT20029 are potential treatments for hair loss, with SCUBE3 stimulating hair growth and GT20029 protecting against DHT. A combined approach using SCUBE3, finasteride or dutasteride, and later GT20029 could provide a comprehensive treatment for androgenetic alopecia.

community What’s the most effective way to beat Serb Derm?

in Treatment 7 upvotes 2 years ago

OP struggles with scalp flakes causing hair loss and has tried Selsun Blue, Ketoconazole, and ZPT Shampoo without success. Suggestions include using salicylic acid shampoo, shaving the head, using Nizoral, and combining treatments like Minoxidil and finasteride.

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Learn

8 / 801 results

learn Ketoconazole

antifungal with some anti-androgenic benefits, often used as a shampoo

learn Minoxidil

An essential vasodilator with some anti-androgenic effects

learn Lavender

plant and natural oil with antimicrobial and some anti-androgenic effects

learn Bicalutamide

Can bicalutamide stop DHT from shrinking your hair follicles? Bicalutamide blocks androgens at the receptor rather than lowering DHT, and some dermatologists prescribe it off-label for women with pattern hair loss. The published evidence is retrospective case series and one small pilot study, with no randomized trial; it is a prescription drug that requires liver monitoring and is contraindicated in pregnancy.

learn Overview

learn Follistatin

How does follistatin compare to finasteride or dutasteride for treating androgenic alopecia? Finasteride and dutasteride are prescription drugs with large controlled trials showing they lower DHT and slow androgenic hair loss, at the cost of documented hormonal side effects; follistatin targets a different, regenerative pathway but has only one small phase 1 human trial behind it, so it is experimental with unknown safety rather than a comparable alternative.

learn Finasteride

Is Finasteride unbeatable or are there equally powerful alternatives? Trials report finasteride as the single medication with the strongest measured effect in male androgenetic alopecia, while dutasteride, minoxidil, topical finasteride, PRP, LLLT and microneedling all have supporting studies and are often reported to work better in combination. Finasteride, dutasteride and oral minoxidil are prescription-only, and several of these uses are off-label.

learn Pyrilutamide

Is pyrilutamide a safer alternative to oral antiandrogens like finasteride? Pyrilutamide may be a safer topical alternative to oral antiandrogens like finasteride.

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