January 2025 in “Open Science Framework” The project aims to validate a nutritional intervention targeting the Redox–NO–Androgen Axis to restore mitochondrial, endothelial, and hormonal balance in male health disorders related to oxidative stress.
March 2026 in “Journal of Multidisciplinary Applied Natural Science” This study reported that Cosmos caudatus extract alone may therapeutically modulate the AR–FGF-2 axis in a BPH rat model, comparable to finasteride, but combining them disrupted pathway regulation, increasing TGF-β levels.
March 2026 in “Journal of Clinical Oncology” In this study, pre-treatment with 5-α-reductase inhibitors (finasteride/dutasteride) in patients with metastatic renal cell carcinoma was associated with better immune checkpoint inhibitor effectiveness and improved progression-free and overall survival, without increasing severe side effects.
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March 2021 in “Hormones” This review discusses how COVID-19 may affect gonadal function and potential gender differences, but reports no clinical results; it highlights possible mechanisms and new treatment approaches from recent literature.
January 2026 in “Scientific Reports” In this study, researchers found that sesamin, a component of sesamum, modulated the AR-MAPK-Wnt signaling pathway in DHT-stimulated HaCaT keratinocytes, demonstrating potential multi-target activity against molecular events in androgenetic alopecia.