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research Increased Androgen Binding Capacity in Sebaceous Glands in Scalp of Male-pattern Baldness

51 citations , January 1989 in “Journal of Investigative Dermatology”

This study found that sebaceous glands in bald scalp have greater androgen binding affinity and capacity than those in hairy scalp, possibly contributing to the androgenic response seen in male pattern baldness.

research 7 Regulation of androgen receptor and 5α-reductase in the skin of normal and hirsute women

35 citations , May 1986 in “Clinics in endocrinology and metabolism”

This study concludes that high skin 5α-reductase activity may contribute to hirsutism, but the specific regulatory mechanisms and genetic factors remain unclear.

research Androgenetic Alopecia: A Chronic or Pubertal Onset Disease Retarded by Blood Donation

September 2017 in “Majallah-i taḥqīqāt-i ̒ulūm-i pizishkī-i Zāhidān”

This study observed that individuals with androgenetic alopecia had abnormal correlations in hematologic parameters, suggesting a chronic, slowly progressing immune-related disorder tied to pubertal androgen secretion.

research EFFECTS OF A LOW‐DOSE DESOGESTREL‐ETHINYLESTRADIOL COMBINATION ON HIRSUTISM, ANDROGENS AND SEX HORMONE BINDING GLOBULIN IN WOMEN WITH A POLYCYSTIC OVARY SYNDROME

53 citations , January 1985 in “Acta obstetricia et gynecologica Scandinavica”

This study found that an 8-month treatment with a low-dose oral contraceptive significantly reduced testosterone levels and hair growth in women with polycystic ovary syndrome and hirsutism, with minimal side effects.

research [Analysis of steroids and binding proteins in the blood of women with androgenetic alopecia].

July 1994 in “PubMed”

In this study, Diane treatment in women with androgenetic alopecia led to normalization of hormone levels and improved hair condition, including less greasiness and reduced hair loss.

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community Clascoterone 5% Delivers Strong Phase 3 Hair-Growth Results

371 upvotes 8 months ago

Clascoterone 5% solution shows strong potential for hair growth, offering a new treatment for alopecia with minimal side effects. It blocks androgen receptors locally and may be available by late 2026 or early 2027.

community Switch from fin to dut and its worse

4 upvotes 1 year ago

Switching from finasteride to dutasteride can worsen hair loss for some men due to increased testosterone levels. Topical treatments like RU58841 and Pyrilutamide are suggested to counteract these effects, but individual responses vary.

community Female, 27 years old, shedding/ balding despite being on what is considered to be a effective treatment plan for AGA. Considering Dut (oral) . Please help.

in Finasteride/Dutasteride 27 upvotes 1 year ago

A 27-year-old woman with androgenic alopecia is losing hair despite using oral minoxidil and spironolactone, and is considering dutasteride. She is exploring causes like stress and medication side effects, planning tests, and considering treatment changes.

community What if DHT is not the vilan.

13 upvotes 5 years ago

Hair loss may be influenced more by inflammation, microbiome imbalances, and gut health than DHT. Treatments discussed include minoxidil, finasteride, RU58841, fecal microbiota transplants, and JAK inhibitors.

community My derm said they came up with a new serum that is better then fin? What’s y’all’s thoughts

7 months ago

A new serum claims to enhance hair regrowth by amplifying oxygen delivery, improving the effectiveness of treatments like exosomes and peptides. Users are skeptical, questioning its efficacy compared to established treatments like Minoxidil and Finasteride.

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