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Did you mean Alpha-Melanocyte-Stimulating Hormone?

Glossary Alpha-Melanocyte-Stimulating Hormone

peptide hormone that regulates skin pigmentation by stimulating melanin production

Alpha-Melanocyte-Stimulating Hormone (α-MSH) is a peptide hormone produced in the pituitary gland that plays a crucial role in regulating skin pigmentation by stimulating the production of melanin in melanocytes. It also has anti-inflammatory properties and can influence appetite and energy homeostasis.

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Research

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research Improved cutaneous wound healing after intraperitoneal injection of alpha‐melanocyte‐stimulating hormone

29 citations , November 2014 in “Experimental Dermatology”

This study found that α-MSH administration before skin wounding in adult mice reduced inflammation and scar area, suggesting a potential pathway to more regenerative healing.

research Non-pigmentary actions of alpha-melanocyte-stimulating hormone--lessons from the cutaneous melanocortin system.

16 citations , May 2006 in “PubMed”

This article reviews the diverse regulatory roles of alpha-melanocyte-stimulating hormone in skin biology, highlighting its potential involvement in maintaining tissue homeostasis and protecting against inflammation-induced DNA damage but reports no new clinical findings.

research Adrenocorticotropic Hormone (ACTH) But Not Alpha-Melanocyte Stimulating Hormone (a-MSH) as a Mediator of Adrenalectomy Induced Hair Growth in Mink

16 citations , April 1998 in “Journal of Investigative Dermatology”

ACTH promotes hair growth in mink, but α-MSH does not.

research 457 Impact of alpha-melanocyte-stimulating hormone on mitochondrial function in human dermal fibroblasts

November 2025 in “Journal of Investigative Dermatology”

Alpha-MSH affects mitochondrial function, and MC1R mutations may increase skin aging.

research Is There a Rationale for the Use of an Alpha-Melanocyte-Stimulating Hormone Analog to Improve Gray Hair Repigmentation?

November 2022 in “Skin Appendage Disorders”

This study found that a 6-month treatment with 2% palmitoyl tetrapeptide 20 showed no significant improvement in reducing hair graying in patients, despite theoretical potential.

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community Peptides that Stop Hair Loss? | In-depth Literature Review Video

76 upvotes 2 years ago

Peptides like TB500, KPV, GHK-CU, and BPC-157 are overhyped for hair growth with limited proven effectiveness in humans. Combining peptides with delivery methods like iontophoresis and sonophoresis shows promise, but many claims remain unproven.

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learn Stem Cell Factor

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

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