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research Expression of the guinea-pig alpha-lactalbumin gene in transgenic mice

January 1990 in “UCL Discovery (University College London)”

This study found that guinea pig α-lactalbumin transgene was expressed in the mammary glands and sebaceous glands of transgenic mice, with milk protein production occurring in the expected secretory acini.

research Comparing the Efficacy of Myo-Inositol Plus α-Lactalbumin vs. Myo-Inositol Alone on Reproductive and Metabolic Disturbances of Polycystic Ovary Syndrome

May 2023 in “Metabolites”

In this study, adding α-lactalbumin to myo-inositol treatment improved ovulation rates, menstrual cycle duration, and hyperandrogenism in women with PCOS more effectively than myo-inositol alone, suggesting potential benefits for those resistant to inositol treatment.

research Therapeutic strategies for treating hair loss

42 citations , March 2006 in “Drug Discovery Today: Therapeutic Strategies”

This article discusses the need for rational strategies in developing hair loss drugs targeting specific events in hair follicle cycling, reporting no clinical findings but emphasizing the importance of understanding molecular controls.

research Serenoa repens and N‐acetyl glucosamine/milk proteins complex differentially affect the paracrine communication between endothelial and follicle dermal papilla cells

3 citations , November 2018 in “Journal of cellular physiology”

In laboratory settings, this study suggests that Serenoa repens and N-acetyl glucosamine with milk proteins may promote hair follicle vascularization through specific cellular interactions and actions.

research New Perspectives on Nutraceutical Insulin Sensitizing Agents in the Treatment of Psoriasis and Other Dermatological Diseases

1 citations , August 2025 in “International Journal of Molecular Sciences”

This narrative review suggests that nutraceutical insulin-sensitizing agents like myo-inositol, alpha-lipoic acid, and vitamins may improve glycemic control and reduce inflammation in insulin resistance-related skin disorders; however, more robust long-term trials are needed to confirm these findings and establish treatment regimens.

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community 17-alpha-estradiol/Alfatradiol how does it Work for Hair loss?

2 upvotes 1 year ago

17-alpha-estradiol may work for hair loss by inhibiting 5-alpha reductase, similar to finasteride. It might lower testosterone in the scalp, reducing DHT conversion.

community 5 alpha reductase type 1 is in brain tissue producing the main endogenous gabaergic allopregnanolone, not 2. How can finasteride as a 5ar2 lower that?

27 upvotes 1 year ago

Finasteride and dutasteride are discussed for hair loss, with concerns about their effects on neurosteroids and potential side effects like depression. Alternatives like topical estrogen and lifestyle changes are considered, with varying opinions on mental health and hair regrowth.

community Mechanism of action of alfatradiol (17 alpha estradiol)

5 upvotes 2 years ago

The conversation discusses the mechanism of action of alfatradiol (17 alpha estradiol) in treating hair loss. It explores theories that it either inhibits 5 alpha reductase to prevent T->DHT conversion or aromatizes scalp T into 17-alpha-estradiol to save hair.

community Has there been any update or progress on the 3-alpha hydroxysteroid dehydrogenase hypothesis?

13 upvotes 2 months ago

The conversation discusses the hypothesis that a lack of the enzyme 3-alpha hydroxysteroid dehydrogenase (3α-HSD) on the scalp may contribute to hair loss by allowing DHT to accumulate. Despite interest in this theory, no recent research has been conducted, and current treatments like finasteride and minoxidil remain the most supported options.

community Which Saw Palmetto is good for blocking 5 alpha reductase, Serenoa repens or Chamaerops humilis?

6 years ago

The conversation is about determining which type of Saw Palmetto, either Chamaerops humilis or Serenoa repens, is effective for inhibiting the 5 alpha reductase enzyme related to hair loss. Specific treatments mentioned are Minoxidil, finasteride, and RU58841.

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