46 citations
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July 2007 in “Journal of the American Academy of Dermatology”
This letter discusses the psychological impact of alopecia areata, highlighting its association with increased depression and anxiety, but reports no new clinical findings.
This study found that dermatologists in the southeastern U.S. often offer less frequent treatment for children with alopecia areata compared to adults, with more treatment also recommended for more advanced stages of hair loss.
Is stemoxydine effective for early-stage thinning and alopecia?Three short, L’Oréal-linked studies in men reported small density gains over vehicle after 3 months. There is no long-term or independent controlled evidence, and no controlled data in women.
What is pyrilutamide, and how does it help with androgenic alopecia or hair loss caused by DHT?Pyrilutamide (KX-826) is an investigational topical antiandrogen designed to block DHT at the androgen receptor in the scalp. Its sponsor reported that a 2023 China Phase III of a 0.5% tincture did not beat placebo and that a 2026 Phase III stage of a 1.0% tincture did; none of the data are peer-reviewed and it is not approved as a medicine anywhere.
Can a zinc deficiency directly cause hair thinning or increased shedding?Studies link low serum zinc to diffuse shedding and alopecia areata, and severe deficiency states cause hair loss that reverses when zinc is replaced. The evidence is mostly observational, the one supplementation study was small and uncontrolled, and zinc is not a treatment for pattern hair loss.
Do alopecia areata patches scar? And is there evidence for peptides?Alopecia areata patches usually still have living follicles and often regrow. One small trial of a cosmetic peptide lotion reported improvement, but no peptide is an approved treatment; see a dermatologist.
A 21-year-old was diagnosed with early-stage androgenetic alopecia and prescribed only minoxidil 5% and ketoconazole shampoo by a dermatologist, who advised against finasteride for now. The user is skeptical about starting minoxidil due to concerns about increased hair loss.
Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.
Caffeine's effectiveness in reversing hair loss is debated, with some users skeptical about caffeine-based products like Alpecin. Alternatives like Nizoral are suggested, but results vary, and some experience side effects from treatments that lower DHT.
Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.
Ketoconazole shampoo may help with early-stage hair loss by stopping hair regression and promoting new hair growth, though its effectiveness as a DHT blocker is debated. Users report varying results, with some experiencing dryness and others seeing improvement when used 2-3 times a week.