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research Role of Allopregnanolone Biosynthesis in Acute Stress-Induced Anxiety-Like Behaviors in Mice

19 citations , April 2017 in “Synapse”

Blocking allopregnanolone production in mice makes them more anxious after stress, but this can be reversed with a drug that mimics allopregnanolone.

research Benzothiazepines, Diltiazem, and JTV-519 Exert Anxiolytic-Like Effects via Neurosteroid Biosynthesis in Mice

1 citations , March 2020 in “Journal of Pharmacological Sciences”

Benzothiazepines like diltiazem reduce anxiety in mice by making neurosteroids.

research Role of Neurosteroid Allopregnanolone on Age-Related Differences in Exercise-Induced Hypoalgesia in Rats

4 citations , November 2018 in “Journal of pharmacological sciences”

Mild exercise reduces pain in older rats through a brain chemical, while intense exercise reduces pain in all rats through a different pain-blocking process.

Treatment With and Withdrawal From Finasteride Alter Ethanol Intake Patterns in Male C57BL/6J Mice: Potential Role of Endogenous Neurosteroids

research Treatment With and Withdrawal From Finasteride Alter Ethanol Intake Patterns in Male C57BL/6J Mice: Potential Role of Endogenous Neurosteroids

54 citations , August 2005 in “Alcohol”

Finasteride affects alcohol intake in male mice, possibly due to neurosteroids.

research Steroidogenesis of the Testis: New Genes and Pathways

70 citations , April 2014 in “Annales d'endocrinologie”

New genes and pathways are important for testosterone production and male sexual development.

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Community Join

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community 1.5 years of Fin, switch 3 months ago to Dut, with 5 moths of Min too

in Progress Pictures 104 upvotes 2 years ago

User switched from Fin to Dut for better hair loss results, using 0.5mg Dut and 1ml Min daily. Some discuss potential side effects and benefits of Dut compared to Fin.

community How finasteride lowers brain's happiness steroid allopregnanolone and causes depression: systemic dihydroprogesterone crosses blood brain barrier, you don't even need finasteride and brain 5ar for that

in Finasteride/Dutasteride 283 upvotes 3 months ago

Finasteride may lower allopregnanolone levels, potentially affecting mood, but many users report improved mental health due to reduced hair loss. Experiences with finasteride and dutasteride vary, with some experiencing side effects and others finding them beneficial for hair retention and overall happiness.

community Debunking the "Adverse metabolic consequences of dutasteride"

in Research/Science 41 upvotes 4 years ago

Dutasteride is more effective than finasteride, has neuroprotective benefits, and may prevent acne. Despite initial concerns about metabolic effects, further research suggests it is safe for most users, especially if not hypogonadal.

community Low cortisol it is due the fin

in Finasteride/Dutasteride 7 upvotes 1 month ago

The user has been taking 1mg finasteride daily for a year with no improvement in hair loss and reports low cortisol levels, sleep issues, and anxiety changes. The conversation includes discussions on the potential effects of finasteride on cortisol and neurosteroids, with suggestions to consult a doctor and consider other factors.

community safety of and efficiency of anti androgens for women

in Female 6 upvotes 3 years ago

27F with androgenic alopecia since 17 seeks treatment. Tried spironolactone, caused low blood pressure; believes finasteride is safer and wants to try it.

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