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Did you mean Alkaline Phosphatase?

Glossary Alkaline Phosphatase

enzyme that breaks down proteins in various body tissues

Alkaline Phosphatase (ALP) is an enzyme found in various tissues throughout the body, including the liver, bones, kidneys, and digestive system. It plays a crucial role in breaking down proteins and is often measured in blood tests to help diagnose liver disease, bone disorders, and other conditions. Elevated or decreased levels of ALP can indicate issues such as liver damage, bone growth abnormalities, or bile duct obstructions.

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Effects of the Anti-Androgen Finasteride on 5α-Reduction of Androgens in the Presence of Progesterone in Human Gingival Fibroblasts: Modulatory Actions of the Alkaline Phosphatase Inhibitor Levamisole

research Effects of the anti-androgen finasteride on 5α-reduction of androgens in the presence of progesterone in human gingival fibroblasts: modulatory actions of the alkaline phosphatase inhibitor levamisole

9 citations , August 2000 in “Journal of Periodontal Research”

Finasteride reduces testosterone conversion, progesterone lessens this, and levamisole enhances finasteride's effect.

research Valproic Acid Induces Hair Regeneration in Murine Model and Activates Alkaline Phosphatase Activity in Human Dermal Papilla Cells

85 citations , April 2012 in “PLOS ONE”

This study found that valproic acid promoted hair re-growth in C3H mice by activating the Wnt/β-catenin pathway, suggesting its potential as a treatment for alopecia.

HaCaT-Conditioned Medium Supplemented with Small Molecule Inhibitors SB431542 and CHIR99021 and Growth Factor PDGF-AA Prevents the Dedifferentiation of Dermal Papilla Cells In Vitro

research HaCaT‑conditioned medium supplemented with the small molecule inhibitors SB431542 and CHIR99021 and the growth factor PDGF‑AA prevents the dedifferentiation of dermal papilla cells in vitro

7 citations , March 2021 in “Molecular Medicine Reports”

This study demonstrated that culturing high-passage dermal papilla cells with specific supplemented conditioned media may preserve their hair-inducing abilities, suggesting potential for reconstructing new hair follicles in vivo.

research TSA restores hair follicle-inductive capacity of skin-derived precursors

18 citations , February 2019 in “Scientific Reports”

This study found that TSA restored the hair-inductive capacity of skin-derived precursors in mice by enhancing BMP gene expression and signaling through histone acetylation.

research 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibition Attenuates the Adverse Effects of Glucocorticoids on Dermal Papilla Cells

3 citations , January 2017 in “Yonsei Medical Journal”

This study found that inhibiting 11β-HSD1 can partially reverse the negative impact of glucocorticoids on dermal papilla cells in human scalps, suggesting potential for treating stress-related hair loss.

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learn Valproic acid

an anticonvulsant repurposed for hair loss via histone inhibition

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