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research A PAX1 enhancer locus is associated with susceptibility to idiopathic scoliosis in females

103 citations , March 2015 in “Nature Communications”

This study identified a genetic locus associated with idiopathic scoliosis in females, which might influence spinal gene expression and was previously linked to protection from early-onset alopecia.

research 2,3,7,8‐Tetrachlorodibenzo‐p‐dioxin causes an increase in protein kinases growth hepatic associated with epidermal factor receptor in the plasma membrane

60 citations , December 1988 in “Journal of Biochemical Toxicology”

In this study, TCDD administered to male rats down-regulated EGF receptor in liver plasma membranes and increased protein kinase activity, suggesting EGF receptor–mediated toxicological effects.

research Identification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31

106 citations , March 2013 in “Nature Communications”

This study found several microRNA-related genetic variants linked to epithelial ovarian cancer risk, with a notable association at the 17q21.31 region, suggesting potential new susceptibility genes.

research Hair of the Dog: Identification of a Cis-Regulatory Module Predicted to Influence Canine Coat Composition

14 citations , April 2019 in “Genes”

This study identified a genetic locus associated with coat type in domestic dogs, showing certain variants linked to single-coated breeds and suggesting potential regulatory roles.

research A Mouse Model of Androgenetic Alopecia

42 citations , March 2010 in “Endocrinology”

This study reports the development of the first rodent model for androgenetic alopecia, demonstrating that overexpression of androgen receptors in mice delays hair regeneration and can be used to test new treatments.

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community We got PP405 hair loss cure being one of the best inventions of 2025 time magazine before GTA 6

in Chat 162 upvotes 11 months ago

PP405 is discussed as a potential hair loss treatment, with doubts about its effectiveness and availability. Users mention using finasteride and minoxidil, and express concerns about PP405's cost and market release.

community So I just continue Finasteride for the rest of my life and I get to keep my hair?

in Finasteride/Dutasteride 157 upvotes 1 year ago

Finasteride can help maintain hair and slow hair loss, but its effectiveness varies by individual. Some may switch to dutasteride or add minoxidil for better results, though side effects are a concern.

community PP405 (Non) Update - Feb 2025

36 upvotes 1 year ago

The conversation discusses the delay in the PP405 Phase 2 study results, now expected by the end of 2025, and skepticism about research practices. There is also mention of optimism for Amplifica's AMP303 and a topical treatment in early testing.

community 8 month journey. 43 years old.

1187 upvotes 10 months ago

A 43-year-old shared an 8-month hair regrowth journey using oral minoxidil, dutasteride, topical minoxidil, ketoconazole shampoo, and lifestyle changes. Commenters noted he looked good both with hair and bald.

community Will PP405 need to be used indefinitely, like minoxidil?

31 upvotes 11 months ago

PP405 may not need daily use like minoxidil, but finasteride might still be needed to maintain hair regrowth. PP405 reawakens dormant hair follicles, potentially offering a long-term solution, though not a permanent cure.

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