Identification and Molecular Characterization of a New Ovarian Cancer Susceptibility Locus at 17q21.31

    March 2013 in “ Nature Communications ”
    Jennifer Permuth‐Wey, Kate Lawrenson, Howard C. Shen, Aneliya Velkova, Jonathan Tyrer, Zhihua Chen, Hui‐Yi Lin, Y. Ann Chen, Ya-Yu Tsai, Xiaotao Qu, Susan J. Ramus, Rod Karevan, Janet Lee, Nathan Lee, Melissa C. Larson, Katja K.H. Aben, Hoda Anton‐Culver, Natalia Antonenkova, Antonis C. Antoniou, Sebastian M. Armasu, François Bacot, Laura Baglietto, Elisa V. Bandera, Jill S. Barnholtz‐Sloan, Matthias W. Beckmann, Michael J. Birrer, Greg Bloom, Natalia Bogdanova, Louise A. Brinton, Angela Brooks‐Wilson, Robert Brown, Ralf Bützow, Qiuyin Cai, Ian Campbell, Jenny Chang‐Claude, Stephen J. Chanock, Georgia Chenevix‐Trench, Jin Q. Cheng, Mine S. Cicek, Gerhard A. Coetzee, Linda S. Cook, Fergus J. Couch, Daniel W. Cramer, Julie M. Cunningham, Agnieszka Dansonka‐Mieszkowska, Evelyn Despierre, Jennifer A. Doherty, Thilo Dörk, Andreas du Bois, Matthias Dürst, Douglas F. Easton, Diana Eccles, Robert P. Edwards, Arif B. Ekici, Peter A. Fasching, David Fenstermacher, James M. Flanagan, Montserrat García‐Closas, Aleksandra Gentry‐Maharaj, Graham G. Giles, Rosalind Glasspool, Jesús González Bosquet, Marc T. Goodman, Martin Gore, Bohdan Górski, Jacek Gronwald, Per Hall, Mari K. Halle, Philipp Harter, Florian Heitz, Peter Hillemanns, Maureen E. Hoatlin, Claus Høgdall, Estrid Høgdall, Satoyo Hosono, Anna Jakubowska, Allan Jensen, Heather Jim, Kimberly R. Kalli, Beth Y. Karlan, Stanley B. Kaye, Linda E. Kelemen, Lambertus A. Kiemeney, Fumitaka Kikkawa, Gottfried E. Konecny, Camilla Krakstad, Susanne K. Kjær, Jolanta Kupryjańczyk, Diether Lambrechts, Sandrina Lambrechts, Johnathan M. Lancaster, Nhu D. Le, Arto Leminen, Douglas A. Levine, Dong Liang, Boon Kiong Lim, Jie Lin, Jolanta Lissowska, Karen H. Lu, Jan Lubiński
    TLDR A new genetic region, 17q21.31, is linked to higher ovarian cancer risk.
    The study investigated the genetic factors contributing to epithelial ovarian cancer (EOC) susceptibility, focusing on miRNA-related single-nucleotide polymorphisms (miRSNPs). Analyzing data from 18,174 EOC cases and 26,134 controls, researchers identified several miRSNPs linked to increased risk of invasive serous EOC, particularly at the 17q21.31 locus. This region, previously associated with neurological diseases, was newly implicated in EOC susceptibility. Further analysis suggested ARHGAP27 and PLEKHM1 as potential EOC susceptibility genes. The findings highlighted the significance of non-coding genetic variants in understanding EOC risk.
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