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research A locus on distal chromosome 10 (ahl4) affecting age-related hearing loss in A/J mice

62 citations , April 2008 in “Neurobiology of aging”

This study identified a new genetic locus, ahl4, on distal Chromosome 10 that contributes to the early-onset, severe hearing loss in A/J mice compared to B6 mice.

research Inositol hexaphosphate alleviates ototoxicity and age‐related hearing loss by preserving cochlear hair cells in mice

November 2025 in “British Journal of Pharmacology”

This study found that inositol hexaphosphate significantly reduced hearing threshold shifts and outer hair cell loss in various sensorineural hearing loss mouse models, suggesting potential for otoprotective use.

research Auditory Threshold Variability in the SAMP8 Mouse Model of Age-Related Hearing Loss: Functional Loss and Phenotypic Change Precede Outer Hair Cell Loss

13 citations , August 2021 in “Frontiers in Aging Neuroscience”

This study found that in SAMP8 mice, phenotypic changes in outer hair cells or the stria vascularis, possibly due to oxidative deficiencies, may predict variability in age-related hearing loss before outer hair cell loss occurs.

research Folate Supplementation and Age-Related Hearing Loss

5 citations , January 2007 in “Annals of Internal Medicine”

Folic acid might help with age-related hearing loss.

research Histopathological change of age-related hearing loss in female advance-aged CBA/CaJ mice

October 2025 in “PLoS ONE”

In this study, researchers investigated age-related hearing loss in advanced-age CBA/CaJ mice and found combined cochlear damage from chronic sound exposure and metabolic changes linked to oxidative stress, which may require addressing both etiologies for prevention and treatment.

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community Age 18 vs Age 25, the importance of starting early

886 upvotes 1 year ago

An 18-year-old began using Finasteride and Topical Minoxidil for hair loss, later switching to Oral Minoxidil and Dutasteride by age 25. The conversation emphasizes early treatment, potential side effects, and differing opinions on medication effectiveness.

community Minoxidil inhibits lysyl hydroxylase which is needed to produce collagen. If I take 2,5...5 mg of minoxidil every day can I cause my skin to age prematurely?

32 upvotes 1 year ago

Oral minoxidil is effective for hair loss and unlikely to significantly affect collagen synthesis, making it a safe option without causing premature skin aging. Users report positive hair regrowth without noticeable skin aging.

community Does anyone plan to microneedle their whole life?

4 upvotes 8 months ago

A 19-year-old is concerned about long-term microneedling for hair loss and is unsure if it will remain effective as they age. They experienced side effects from topical finasteride and are considering whether to try it again in the future, while also dealing with body dysmorphia and stress.

community A man in his 80s with full head of hair.

473 upvotes 4 months ago

Genetics play a major role in hair loss, with some people keeping a full head of hair into old age without using treatments like minoxidil or finasteride. Many express frustration over their own hair loss and the perceived unfairness of genetic differences.

community Creatine and hair loss...you're not crazy.

8 upvotes 7 months ago

Creatine may increase DHT levels, potentially causing hair loss in some people, though experiences vary. Treatments like finasteride or minoxidil are suggested to manage potential hair loss.

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learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

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