183 citations
,
January 1987 in “British Journal of Anaesthesia”
This article discusses the long-standing use and safety of opioids in anaesthesia, noting that respiratory depression is a manageable side effect due to the availability of opioid antagonists.
121 citations
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June 2010 in “Australasian Journal of Dermatology”
This study observed that isotretinoin has a low adverse-effect profile, with most side effects being dose-dependent and reversible, except for rare severe cases leading to discontinuation.
100 citations
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September 2016 in “Clinical transplantation/Clinical transplantation.”
This study highlights that prolonged voriconazole use is linked to an increased risk of aggressive cutaneous malignancies like squamous cell carcinoma, necessitating careful monitoring of drug levels to manage adverseeffects.
Oral minoxidil is considered a safe and effective treatment for hair loss at low dosages, with minimal cardiac risks. Users report positive results, though some experience side effects like increased heart rate and skin changes, and consulting a doctor is advised.
Diclofenac is not effective for hair loss, and using it on the scalp can cause adverseeffects. Minoxidil, finasteride, and microneedling are suggested treatments, while checking vitamin and mineral levels is also recommended.
Dutasteride is more effective than finasteride for hair loss, especially at the crown and midscalp, but both have similar side-effect profiles with low incidence of sexual adverse events. Improvement is measured visually, and significant results may take over 12 months to appear.
Natural DHT blockers caused negative side effects like weak erections and depression, while finasteride improved overall well-being and cleared acne. Users shared similar experiences, finding finasteride effective without the adverseeffects of natural treatments.
Is HMI-115 considered a safe option, or does it have strong side effects?HMI-115 is an experimental injected antibody, not a hormone blocker: the one published trial (in endometriosis) reported an acceptable 12-week tolerability profile with no treatment-related serious adverse events, and no peer-reviewed safety data exists for its use in hair loss.
Is azelaic acid safe to use daily long-term?Azelaic acid has a long tolerability record on facial skin in acne and rosacea, where side effects are local and usually mild — but for daily long-term scalp use the only trial is one six-month study in 26 women, in which mild itching was the main adverse effect, so long-term scalp safety is not established.