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research Advanced chemical imaging and comparison of human and porcine hair follicles for drug delivery by confocal Raman microscopy

27 citations , November 2012 in “Journal of Biomedical Optics”

This study used confocal Raman microscopy to confirm optical similarity between human and porcine hair follicles, supporting its use in assessing trans-follicular drug delivery.

research Advances and challenges in intravital imaging of craniofacial and dental progenitor cells

2 citations , August 2022 in “genesis”

This review explores current advancements and applications of intravital imaging techniques for studying stem/progenitor cells in craniofacial and dental tissues, but it reports no new experimental findings.

research Novel insights into hair structure and the effects of chemical stressors on hair and skin using label-free advanced light microscopy

January 2017 in “Durham e-Theses (Durham University)”

This study developed new label-free imaging methods to analyze human hair, identifying distinct chemical environments within cuticle layers and changes in hair structure caused by depilatories, while showing that the treatments tested did not significantly affect skin cell differentiation or proliferation.

research Targeting integrin pathways: mechanisms and advances in therapy

54 citations , January 2023 in “Signal Transduction and Targeted Therapy”

This review examines integrins as pharmacological targets, discussing current integrin-based therapies and emphasizing the need to understand integrin mechanisms for successful drug development, without reporting new clinical results.

research Optimization of menthol-loaded nanocapsules for skin application using the response surface methodology

25 citations , July 2019 in “Journal of drug delivery science and technology”

This study developed lipid-core nanocapsules for encapsulating menthol, improving its solubility and thermal stability, and demonstrated their safety and rapid skin absorption in ex vivo tests, highlighting potential applications for cosmeceuticals.

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Community Join

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community If fin/min and advanced treatments don’t work—would you ever consider a hair system? Or just shave it and own it?

in Chat 42 upvotes 1 year ago

If treatments like finasteride, minoxidil, PRP, microneedling, and exosomes fail, opinions differ on using a hair system or shaving. Some choose shaving for simplicity, while others consider hair systems despite maintenance concerns.

community How is there zero improvement with finding the cure?

in Research/Science 245 upvotes 7 months ago

Hair loss treatments have not advanced since 2018, with finasteride, minoxidil, and RU58841 still being the main options. A permanent cure is unlikely due to the profitability of ongoing treatments.

community Is pp405 actually the cure ? Just how exciting is it ?

36 upvotes 9 months ago

PP405 is a promising hair growth stimulant but not a cure for advanced hair loss, as it may only help dormant follicles. Treatments like Minoxidil, Finasteride, and Dutasteride are discussed, with emphasis on early intervention for effectiveness.

community PP405 - A True Breakthrough or Another Disappointment?

34 upvotes 1 year ago

PP405 shows potential for hair growth, with 31% of advanced balding men experiencing over 20% increase in hair density in 8 weeks. However, skepticism persists due to selective data presentation and lack of long-term results, with comparisons to treatments like minoxidil and finasteride.

community This could be it!!! New treatment increase hair 500%

340 upvotes 9 months ago

Clascoterone (Breezula) shows a potential 500% increase in hair growth, possibly outperforming minoxidil and finasteride. It is in advanced trials, with hopes for FDA approval, but cost and side effects are concerns.

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Learn

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learn Thymosin Beta 4

How is Thymosin Beta 4 typically incorporated into experimental or advanced hair growth products? Thymosin Beta 4 is not an ingredient in any approved or regulated hair-loss product — it is an unapproved research peptide (sold online as TB-500). Published hair studies are in rats and mice only, from one research group; there are no human trials, and the same literature reports it can promote tumour growth.

learn Exosomes

Do exosomes work for people with mild hair loss or only in advanced cases? There is no approved exosome treatment for hair loss and no controlled trial in either mild or advanced cases; the argument that early thinning would respond better is based on follicle biology, not on results.

learn sh-Polypeptide-7

What is sh-Polypeptide-7 and why is it used in some advanced hair serums and treatments? sh-Polypeptide-7 is a synthetic peptide that supports hair growth and scalp regeneration.

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Clinics

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