29 citations
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March 2017 in “International Journal of Women's Dermatology” This review found that combined oral contraceptives and spironolactone are effective treatments for adult acne in women, but noted that oral contraceptives increase the risk of venous thromboembolism and require individual risk assessment before use.
117 citations
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February 2017 in “American Journal of Clinical Dermatology” This systematic review concluded that the support for using spironolactone at commonly prescribed doses is based on evidence of limited quality.
April 2021 in “International Journal of Research in Dermatology” This study found that hormonal abnormalities are not very common in adult females with acne, although some patients showed indicators of hyperandrogenism.
9 citations
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April 2015 in “Dermatologic Therapy” This review discusses the use of hormonal therapies for managing acne vulgaris in adult women and reports no new clinical results, emphasizing the chronic and severe nature of acne in this population.
January 2026 in “IOSR Journal of Dental and Medical Sciences” In this cross-sectional study, researchers observed that acne vulgaris is highly prevalent among adults and found that inadequate sleep is significantly associated with more severe acne, while diet and stress showed no significant link. Additionally, acne negatively impacts psychosocial well-being, affecting individuals' social interactions.