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    GlossaryAdrenal Insufficiency (Adrenal Failure)

    occurs when adrenal glands produce insufficient cortisol and aldosterone

    Adrenal Insufficiency, also known as adrenal failure or adrenal hypofunction, is a condition where the adrenal glands do not produce enough of certain hormones, particularly cortisol and sometimes aldosterone. This can lead to symptoms such as fatigue, muscle weakness, weight loss, low blood pressure, and skin changes. It can be caused by autoimmune disorders, infections, or other underlying health issues, and requires medical diagnosis and management.

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      a synthetic cortisol used for anti-inflammatory effects

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      research Varying Presentation of Type 1 Polyglandular Failure in India

      4 citations, January 2010 in “Journal of pediatric endocrinology & metabolism/Journal of pediatric endocrinology and metabolism”
      In India, most patients with type 1 autoimmune polyglandular failure show symptoms in a specific order, starting with parathyroid gland issues, then yeast infections, and finally adrenal gland failure.

      research Autoimmune Polyglandular Syndrome Type 2, Alopecia Universalis, and Crohn's Disease

      8 citations, June 2012 in “Journal of Crohn s and Colitis”
      A 33-year-old male with a history of Crohn's colitis diagnosed in childhood experienced sudden hair loss in 2003, leading to a diagnosis of alopecia universalis. At age 28, he was hospitalized with severe dehydration and ketoacidosis, revealing diabetes mellitus type 1. In 2005, he had a severe relapse of Crohn's disease and was treated with systemic corticosteroids. Despite initial improvement, he developed fatigue, hypotension, and bradycardia, leading to a diagnosis of Hashimoto thyroiditis and adrenal cortex failure. Managing his diabetes, hypothyroidism, adrenal insufficiency, and Crohn's disease proved extremely challenging despite intensive treatment.
      COVID-19 and Hypopituitarism

      research COVID-19 and Hypopituitarism

      15 citations, August 2021 in “Reviews in endocrine and metabolic disorders”
      COVID-19 and hypopituitarism (reduced pituitary gland function) are linked, with the latter's related health issues potentially worsening COVID-19 outcomes, and COVID-19 possibly increasing risk for pituitary complications.

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