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    Glossary Integrin

    Integrins are transmembrane proteins that play a crucial role in cell adhesion, signaling, and communication within the extracellular matrix. In the context of hair biology, integrins are involved in the regulation of hair follicle development, cycling, and the interaction between hair follicle cells and their surrounding environment. Their relevance to hair loss lies in their influence on the health and function of hair follicles; disruptions in integrin signaling can contribute to conditions such as alopecia and other forms of hair thinning. Key distinguishing characteristics of integrins include their ability to bind to specific ligands and their role in mediating cellular responses to mechanical and biochemical signals.

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    1. Targeting integrin pathways: mechanisms and advances in therapy Signal Transduction and Targeted Therapy · 2023 · 54 citations
    2. α3β1-integrin regulates hair follicle but not interfollicular morphogenesis in adult epidermis Journal of Cell Science · 2003 · 45 citations
    3. β1 Integrin Signaling Maintains Human Epithelial Progenitor Cell Survival In Situ and Controls Proliferation, Apoptosis and Migration of Their Progeny PLoS ONE · 2013 · 20 citations
    4. β1 Integrins with Individually Disrupted Cytoplasmic NPxY Motifs Are Embryonic Lethal but Partially Active in the Epidermis Journal of Investigative Dermatology · 2013 · 17 citations
    5. The microanatomy of the distal arrector pili: possible role for α1β1 and α5β1 integrins in mediating cell‐cell adhesion and anchorage to the extracellular matrix Journal of Cutaneous Pathology · 2000 · 15 citations
    6. Keratinocyte integrin α3β1 induces expression of the macrophage stimulating factor, CSF-1, through a YAP/TEAD-dependent mechanism. Matrix Biology · 2024 · 8 citations
    7. Blocking <i>α</i>1‐integrin reverts the adhesive phenotype of adult fibroblasts towards a foetal‐like migratory phenotype Experimental Dermatology · 2016 · 4 citations
    8. Beta 1 Integrin in Hair Follicles of Patients with Androgenetic Alopecia Benha Journal of Applied Sciences · 2024
    9. Regulatory Effects of YiFa Compound Medicated Serum on Proliferation of Follicle Stem Cells and mRNA Expression of K19 and β1 Integrin Chinese Journal of Dermatovenereology of Integrated Traditional and Western Medicine · 2013
    10. Regulatory effect of astraglus polysaccharide on proliferation of follicle stem cells and mRNA expression of its specific marker:K19 and β1 integrin Shiyong yixue zazhi · 2013
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    Community 4

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