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    Glossary Integrin

    Integrins are transmembrane proteins that play a crucial role in cell adhesion, signaling, and communication within the extracellular matrix. In the context of hair biology, integrins are involved in the regulation of hair follicle development, cycling, and the interaction between hair follicle cells and their surrounding environment. Their relevance to hair loss lies in their influence on the health and function of hair follicles; disruptions in integrin signaling can contribute to conditions such as alopecia and other forms of hair thinning. Key distinguishing characteristics of integrins include their ability to bind to specific ligands and their role in mediating cellular responses to mechanical and biochemical signals.

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    1. Targeting integrin pathways: mechanisms and advances in therapy Signal Transduction and Targeted Therapy · 2023 · 54 citations
    2. α3β1-integrin regulates hair follicle but not interfollicular morphogenesis in adult epidermis Journal of Cell Science · 2003 · 45 citations
    3. β1 Integrin Signaling Maintains Human Epithelial Progenitor Cell Survival In Situ and Controls Proliferation, Apoptosis and Migration of Their Progeny PLoS ONE · 2013 · 20 citations
    4. β1 Integrins with Individually Disrupted Cytoplasmic NPxY Motifs Are Embryonic Lethal but Partially Active in the Epidermis Journal of Investigative Dermatology · 2013 · 17 citations
    5. The microanatomy of the distal arrector pili: possible role for α1β1 and α5β1 integrins in mediating cell‐cell adhesion and anchorage to the extracellular matrix Journal of Cutaneous Pathology · 2000 · 15 citations
    6. Keratinocyte integrin α3β1 induces expression of the macrophage stimulating factor, CSF-1, through a YAP/TEAD-dependent mechanism. Matrix Biology · 2024 · 8 citations
    7. Blocking <i>α</i>1‐integrin reverts the adhesive phenotype of adult fibroblasts towards a foetal‐like migratory phenotype Experimental Dermatology · 2016 · 4 citations
    8. Beta 1 Integrin in Hair Follicles of Patients with Androgenetic Alopecia Benha Journal of Applied Sciences · 2024
    9. Regulatory Effects of YiFa Compound Medicated Serum on Proliferation of Follicle Stem Cells and mRNA Expression of K19 and β1 Integrin Chinese Journal of Dermatovenereology of Integrated Traditional and Western Medicine · 2013
    10. Regulatory effect of astraglus polysaccharide on proliferation of follicle stem cells and mRNA expression of its specific marker:K19 and β1 integrin Shiyong yixue zazhi · 2013
    11. Epithelial Integrity Is Maintained by a Matriptase-Dependent Proteolytic Pathway ˜The œAmerican journal of pathology · 2009 · 137 citations
    12. Polarity signaling ensures epidermal homeostasis by coupling cellular mechanics and genomic integrity Nature Communications · 2019 · 38 citations
    13. Sebaceous lipids are essential for water repulsion, protection against UVB-induced apoptosis, and ocular integrity in mice Development · 2016 · 32 citations
    14. Incubatory environment of the scalp impacts pre‐emergent hair to affect post‐emergent hair cuticle integrity Journal of cosmetic dermatology · 2017 · 16 citations
    15. Evaluation of short-term hair follicle storage conditions for maintenance of RNA integrity PLoS ONE · 2024 · 1 citations
    16. Centrifugation Determines What Is in the Syringe, Not What Happens to the Patient: A Systematic Meta-Analysis of Platelet-Rich Plasma Preparation, Platelet Integrity, Cell Counts, Growth Factors and Clinical Outcomes in Regenerative Medicine Journal Of Stem Cell Research · 2026
    17. Molecular Predictors of Ritlecitinib Efficacy in Alopecia Areata: Role of JAK3-Dependent Inflammation and Follicular Integrity 2025
    18. LB1256 TRIV-509, a dual inhibitor of KLK5 and KLK7, rapidly improves barrier integrity and markers of epidermal differentiation in atopic dermatitis skin explants Journal of Investigative Dermatology · 2025
    19. Hair Integrity and Health with Dieting 2025
    20. 259 Scalp hair follicle dermal sheath fibroblasts express genes associated with promotion of skin integrity/wound healing and prevention of autoimmune responses in Recessive Dystrophic Epidermolysis Bullosa Journal of Investigative Dermatology · 2024
    21. Evaluation of short-term hair follicle storage conditions for maintenance of RNA integrity bioRxiv (Cold Spring Harbor Laboratory) · 2023
    22. Integrin signalling regulates YAP/TAZ to control skin homeostasis Development · 2016 · 266 citations
    23. Rac1 Is Crucial for Hair Follicle Integrity but Is Not Essential for Maintenance of the Epidermis Molecular and Cellular Biology · 2006 · 139 citations
    24. The focal adhesion protein PINCH-1 associates with EPLIN at integrin adhesion sites Journal of Cell Science · 2015 · 28 citations
    25. Targeted inactivation of integrin-linked kinase in hair follicle stem cells reveals an important modulatory role in skin repair after injury Molecular Biology of the Cell · 2011 · 22 citations
    26. Hair-Growth-Promoting Effect of Conditioned Medium of High Integrin α6 and Low CD 71 (α6bri/CD71dim) Positive Keratinocyte Cells International Journal of Molecular Sciences · 2015 · 17 citations
    27. miR-3606-3p alleviates skin fibrosis by integratively suppressing the integrin/FAK, p-AKT/p-ERK, and TGF-β signaling cascades Journal of Advanced Research · 2024 · 15 citations
    28. Essential Role for Integrin-Linked Kinase in Melanoblast Colonization of the Skin Journal of Investigative Dermatology · 2019 · 14 citations
    29. Integrin β1 Establishes Liver Microstructure and Modulates Transforming Growth Factor β during Liver Development and Regeneration American Journal Of Pathology · 2020 · 10 citations
    30. Multiple Roles of Integrin-Linked Kinase in Epidermal Development, Maturation and Pigmentation Revealed by Molecular Profiling PLOS ONE · 2012 · 9 citations