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research The enzyme and inhibitors of 4-ene-3-oxosteroid 5α-oxidoreductase

64 citations , June 1995 in “Steroids”

This review discusses biochemical studies on 5 alpha-reductase and its inhibitors, comparing IC50 and Ki values for various compounds, but reports no new experimental results.

Treatment of Male Rats with Finasteride, an Inhibitor of 5alpha-Reductase Enzyme, Induces Long-Lasting Effects on Depressive-Like Behavior, Hippocampal Neurogenesis, Neuroinflammation, and Gut Microbiota Composition

research Treatment of male rats with finasteride, an inhibitor of 5alpha-reductase enzyme, induces long-lasting effects on depressive-like behavior, hippocampal neurogenesis, neuroinflammation and gut microbiota composition

37 citations , September 2018 in “Psychoneuroendocrinology”

This study found that finasteride treatment in male rats led to enduring effects on depressive-like behavior, hippocampal neurogenesis and neuroinflammation, and gut microbiota composition after withdrawal.

research The Neurosteroidogenic Enzyme 5α-Reductase Mediates Psychotic-Like Complications of Sleep Deprivation

27 citations , January 2017 in “Neuropsychopharmacology”

This study found that acute sleep deprivation enhanced 5α-reductase expression and activity in the rat prefrontal cortex, and finasteride treatment reduced associated psychosis- and mania-like behaviors.

research Fast Motions in 5 Alpha Reductase and Its Impact on Enzyme Kinetics

May 2026 in “ACS Catalysis”

In this study, researchers using QM/MM simulations identified key molecular motions and residue interactions in the enzyme SRD5A2 that significantly influence its catalytic efficiency, demonstrating that specific residues play critical roles in stabilizing transition states and reducing activation barriers.

research Enzyme Inhibitory Activities of Marine Sponges Against Cholinesterase and 5α-Reductase

June 2019

This study reported that methanolic extracts from marine sponges, particularly Petrosia sp. and Agelas nakamurai, showed significant enzyme inhibitory activities, with Petrosia sp. exhibiting notable 5?-reductase inhibition.

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Community Join

5 / 377 results

community Did anybody use beta sisterol for hair loss? I saw in many articles in the internet that said that beta sisterol blocks dht by inhibiting 5a reductase type 2 enzyme and some reviews of people who said that it worked better than saw palmetto in terms of stoping hair loss and helping prostate.

in Research/Science 9 upvotes 3 years ago

Beta-sitosterol may inhibit 5-alpha reductase type 2 enzyme, potentially reducing DHT levels and promoting hair growth, similar to finasteride but possibly with fewer side effects. Its effectiveness and side effects compared to other treatments like saw palmetto and finasteride remain uncertain due to limited research.

community Which Saw Palmetto is good for blocking 5 alpha reductase, Serenoa repens or Chamaerops humilis?

6 years ago

The conversation is about determining which type of Saw Palmetto, either Chamaerops humilis or Serenoa repens, is effective for inhibiting the 5 alpha reductase enzyme related to hair loss. Specific treatments mentioned are Minoxidil, finasteride, and RU58841.

community Was scared to try fin and jumped straight to 2.5mg Dut?

36 upvotes 3 days ago

The user started with oral minoxidil and switched to 2.5mg dutasteride, experiencing significant hair growth without side effects. They believe dutasteride has fewer side effects than finasteride due to its action on both type 1 and 2 5-alpha reductase enzymes.

community 5 years on topical finasteride, 3.5 years on oral minoxidil; now changing from finasteride to dutasteride

133 upvotes 2 weeks ago

A 66-year-old male experienced significant hair regrowth using topical finasteride for 5 years and oral minoxidil for 3.5 years, with no side effects. He is now switching from finasteride to topical dutasteride while continuing oral minoxidil to potentially improve results further.

community 5 years on topical finasteride, 3.5 years on oral minoxidil; now changing from finasteride to dutasteride

in Finasteride/Dutasteride 3 upvotes 2 weeks ago

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Learn

6 / 801 results

learn procapil

Want to stop hormonal hair loss without touching your hormone levels? Procapil could block the enzyme doing the damage. Procapil's supplier describes it as inhibiting 5-alpha reductase at the scalp without changing hormone levels, but the published support is cell and animal work plus one small human study of a caffeine-plus-Procapil formula. It is a cosmetic ingredient, not an approved hair-loss treatment, and no trial has compared it with finasteride or minoxidil.

learn Finasteride

Frontline, gold standard treatment for combatting androgenic alopecia

learn Saw Palmetto

a natural and far less effective alternative to Finasteride

learn Azelaic Acid

acid used for antimicrobial, anti-inflammatory and anti-androgenic properties

learn Rosemary

herb and oil with stimulant, circulatory, anti-inflammatory and antioxidant properties

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

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