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research Synthesis of novel andostane-N-cyclohexyl-17-carboxamides, and their effect on the 5α-reductase isoform 2, the androgen receptor, and androgen-dependent glands

November 2021 in “Pharmaceutical Sciences”

This study found that the compound androstane-17-carboxamide 6 may serve as a lead for new drugs to treat BPH and prostate cancer by reducing the weight of androgen-dependent glands.

research Selected variants of the steroid-5-alpha-reductase isoforms SRD5A1 and SRD5A2 and the sex steroid hormone receptors ESR1, ESR2 and PGR: No association with female pattern hair loss identified

18 citations , February 2012 in “Experimental Dermatology”

This study found no significant association between selected gene variants and female pattern hair loss, suggesting these genes might not be involved in its development.

research The 5α-Recluctase System and Its Inhibitors

124 citations , January 1996 in “Dermatology”

This article reviews the biochemical properties of 5 alpha-reductase isoforms and highlights the limited dermatological use of inhibitors like finasteride, especially for type 1 isozyme-targeting agents, while suggesting further clinical exploration.

research Predominant expression of 5 alpha-reductase type 1 in pubic skin from normal subjects and hirsute patients.

11 citations , May 1996 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism”

This study reported that 5 alpha-reductase type 2 is the predominant enzyme in pubic skin fibroblasts across normal men, women, and hirsute patients, suggesting potential treatment options for idiopathic hirsutism.

research Determination of the potency of a novel saw palmetto supercritical CO2 extract (SPSE) for 5α-reductase isoform II inhibition using a cell-free in vitro test system

3 citations , April 2016 in “Research and reports in urology”

In a cell-free test setting, this study found that a novel saw palmetto extract effectively inhibited the 5α-reductase type II enzyme, showing promising bioactivity comparable to finasteride for promoting prostate health.

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community FCE 28260: A Forgotten 5α-Reductase Inhibitor

in Research 330 upvotes 2 years ago

FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

community 5 years on topical finasteride, 3.5 years on oral minoxidil; now changing from finasteride to dutasteride

133 upvotes 4 weeks ago

A 66-year-old male experienced significant hair regrowth using topical finasteride for 5 years and oral minoxidil for 3.5 years, with no side effects. He is now switching from finasteride to topical dutasteride while continuing oral minoxidil to potentially improve results further.

community I reduced my serum DHT by 60% without Fin/Dut but not seeing any real stabilization or growth

in Update 2 upvotes 1 year ago

The user reduced serum DHT by 60% using Advanced Trichology's natural DHT blocker but saw no improvement in hair loss. They are considering switching to finasteride due to its proven effectiveness in inhibiting scalp DHT.

community Any growth (been taking iron supplements)

in Is this regrowth? 1 year ago

The conversation discusses hair loss treatments, focusing on iron supplements for low ferritin levels and considering finasteride and minoxidil if thinning persists. There is debate over starting with finasteride versus dutasteride, with some users advocating for dutasteride due to its potency, while others caution about potential side effects.

community Long time users of Dut/Fin, what would you do differently if you had to start all over?

23 upvotes 1 year ago

People shared experiences with hair loss treatments like Minoxidil, Finasteride, and Dutasteride. Opinions varied on effectiveness and side effects, with advice to start early and adjust dosages based on individual reactions.

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learn Dutasteride

5-alpha reductase inhibitor that blocks both enzyme types, a stronger DHT blocker than finasteride

learn Finasteride

Popular 5-alpha reductase inhibitor that lowers DHT, taken as a pill or used topically

learn procapil

Does Procapil block DHT without affecting hormones? What the evidence shows Procapil's supplier describes it as inhibiting 5-alpha reductase at the scalp without changing hormone levels, but the published support is cell and animal work plus one small human study of a caffeine-plus-Procapil formula. It is a cosmetic ingredient, not an approved hair-loss treatment, and no trial has compared it with finasteride or minoxidil.

learn white tea

Can white tea help reduce DHT-related hair thinning in androgenic alopecia? In lab tests, tea catechins blocked type 1 (not type 2) 5-alpha-reductase; no human study shows white tea lowers scalp DHT or reduces hair thinning.

learn Fluridil

How is Fluridil different from other DHT blockers like finasteride? Fluridil is a topical androgen-receptor blocker applied to the scalp, while finasteride is an oral 5-alpha-reductase inhibitor that lowers DHT throughout the body. Finasteride is FDA-approved and far better studied; Fluridil rests on one 43-man trial and is not licensed as a hair-loss medicine, so its long-term safety and effect size are unknown.

learn Omega 3

Is the omega-3 to omega-6 ratio in your diet feeding your hair problem without you knowing? Nutrition sources describe a lopsided omega-6 to omega-3 intake as pro-inflammatory, but no published human study shows that the dietary ratio changes 5-alpha reductase, scalp DHT or hair loss; the one relevant trial tested a commercial omega-3/6 plus antioxidant supplement in 120 women, not a change in dietary fat ratio.

learn Ecklonia Cava

Can Ecklonia Cava be used as a preventive treatment for early signs of hair thinning? No human trial has tested Ecklonia cava for hair loss, so it cannot be called preventive; the evidence is mouse studies and cell cultures suggesting antioxidant activity and 5-alpha-reductase inhibition in the lab.

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