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    GlossarySteroid 5 Alpha-Reductase 1

    converts testosterone into a more potent androgen, dihydrotestosterone

    Steroid 5 Alpha-Reductase 1 (SRD5A1) is an enzyme that converts testosterone into dihydrotestosterone (DHT), a more potent androgen hormone. This enzyme plays a significant role in the development of male characteristics and is also implicated in conditions like androgenic alopecia (male pattern baldness) and benign prostatic hyperplasia.

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      Frontline, gold standard treatment for combatting androgenic alopecia

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      FCE 28260: A Forgotten 5α-Reductase Inhibitor

      community FCE 28260: A Forgotten 5α-Reductase Inhibitor

      in Research  330 upvotes 2 months ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.