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research Effects on Steroid 5-Alpha Reductase Gene Expression of Thai Rice Bran Extracts and Molecular Dynamics Study on SRD5A2

14 citations , April 2021 in “Biology”

This study found that ethanol extract of Tubtim Chumphae rice bran downregulates SRD5A gene expression, similarly to finasteride, suggesting potential use as an anti-hair loss product.

research No elevated risk for osteoporosis or osteopenia among women with androgenetic or frontal fribrosing alopecia treated with 5-alpha reductase inhibitors: A retrospective TriNetX cohort study

January 2026 in “Journal of the American Academy of Dermatology”

5-alpha reductase inhibitors do not increase osteoporosis risk in women with certain hair loss conditions.

research Risk of Estrogen-Driven Malignancies in Females on 5-alpha Reductase Inhibitors

August 2024 in “Research Square (Research Square)”

This study found that women taking 5α-reductase inhibitors (5aRI) for alopecia had a lower risk of breast cancer compared to those not using these medications, with no increased risk of developing ovarian or endometrial cancer.

research The risk of dementia with the use of 5 alpha reductase inhibitors

18 citations , June 2017 in “Journal of the neurological sciences”

In this study, the use of 5 alpha reductase inhibitors was associated with an increased risk of dementia during the first two years of treatment, but the risk was not significant with longer exposure.

research The Risk of Venous Thromboembolism (VTE) in Men with Benign Prostatic Hyperplasia Treated with 5-Alpha Reductase Inhibitors (5ARIs).

6 citations , August 2021 in “Clinical Epidemiology”

Men using 5-alpha reductase inhibitors for prostate issues may have a slightly higher risk of blood clots.

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community Crown Comeback - Rise from the dead

in Progress Pictures 1171 upvotes 1 year ago

The user shared their successful hair regrowth journey using minoxidil 5% twice daily and weekly microneedling. Other users suggested adding finasteride to maintain gains long-term.

community What About Phytosterol Alternatives - Rice Bran Oil - Natural DHT Blockers

3 upvotes 2 years ago

The conversation discusses natural DHT blockers like rice bran oil, which may reduce 5α-reductase activity similarly to Minoxidil and Dutasteride. One user argues that finasteride is more reliable and effective than natural alternatives.

community Finasteride is a risk in pregnancy with unprotected sex

118 upvotes 6 years ago

Finasteride may pose a risk during pregnancy, so using a condom is recommended if a partner is pregnant. It is advised to stop finasteride before trying to conceive due to potential effects on fetal development.

community 5 alpha reductase type 1 is in brain tissue producing the main endogenous gabaergic allopregnanolone, not 2. How can finasteride as a 5ar2 lower that?

27 upvotes 1 year ago

Finasteride and dutasteride are discussed for hair loss, with concerns about their effects on neurosteroids and potential side effects like depression. Alternatives like topical estrogen and lifestyle changes are considered, with varying opinions on mental health and hair regrowth.

community How much more risk does TRT really put on hair?

2 upvotes 1 month ago

TRT may increase hair loss, but using treatments like dutasteride, minoxidil, and RU58841 can help mitigate it. Individual responses vary, and some users report regrowth while others see stabilization or continued loss.

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