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research Follicular delivery of a novel peptide therapeutic for the treatment of androgenic alopecia

December 2015

In this study, a novel liposomal peptide formulation significantly enhanced hair growth in mice compared to minoxidil, but results on human tissue penetration were inconclusive, suggesting further research is needed for translation to human use.

research Sebum Free Fatty Acids Enhance the Innate Immune Defense of Human Sebocytes by Upregulating β-Defensin-2 Expression

195 citations , December 2009 in “Journal of Investigative Dermatology”

This study found that sebum free fatty acids may enhance the antibacterial defense of human sebaceous glands by upregulating the expression of the antimicrobial peptide hBD-2, potentially aiding in acne treatment.

research Cell Surface B2m-Free Human Leukocyte Antigen (HLA) Monomers and Dimers: Are They Neo-HLA Class and Proto-HLA?

3 citations , July 2023 in “Biomolecules”

This study reports that some human cell surface HLA-I molecules (including HLA-B27) can appear without their usual peptide component, potentially altering immune interactions, influencing arthritis development in specific mice models, and exhibiting upregulation in certain cancer cells.

research Linagliptin-Associated Alopecia and Bullous Pemphigoid

7 citations , September 2019 in “European Journal of Case Reports in Internal Medicine”

This case report describes a 68-year-old man who developed both alopecia areata and bullous pemphigoid after starting linagliptin for diabetes, suggesting a possible link with DPP-4 inhibitors.

research Regulated Proenkephalin Expression in Human Skin and Cultured Skin Cells

77 citations , December 2010 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that human skin expresses proenkephalin, whose expression is upregulated by environmental stress and varies in pathological conditions, increasing in psoriasis and decreasing in melanocytic tumors.

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Learn

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learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Epidermal Growth Factor

learn Raspberry Ketone

learn Scalp Micropigmentation

How long does Scalp Micropigmentation last, and does it need touch-ups over time? Scalp micropigmentation lasts 2 to 8 years and requires touch-ups every 1 to 5 years.

learn Hair Transplant

How long does a hair transplant procedure take? A hair transplant procedure typically takes 4 to 8 hours.
How much do 2000 hair grafts cost? The cost for 2000 hair grafts typically ranges from $500 to $12,800.
How much do 5000 grafts cost in Turkey? The cost for 5000 grafts in Turkey typically ranges from $1,100 to $8,900.
All 4 questions on Hair Transplant →

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Community Join

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community Amplifica: Hope or Cope? A Review of Their Pipeline

9 upvotes 1 month ago

Amplifica's AMP-303 showed a modest increase in hair growth, but results were inconsistent and potentially misleading. Hyaluronic acid and osteopontin are being explored for hair growth, with varying effects on different hair types and conditions.

community 4 years (2 years fina, soon 2 years Dut) and topical / oral min

in Progress Pictures 5 upvotes 5 months ago

The user started hair loss treatment at 19 with oral finasteride and topical minoxidil, later switching to oral Dutasteride and oral minoxidil. Despite ongoing treatments, including microneedling and topical applications, hair loss, particularly at the hairline, continues to progress.

community 4 1/2 months of Dut and Oral Min Update

377 upvotes 7 months ago

Significant hair regrowth was achieved after 4.5 months using 0.5 mg Dutasteride and 5 mg oral Minoxidil. Tips on obtaining prescriptions and discussions on effectiveness and side effects were also shared.

community 42 male - 8 months (Is this the biological limit?)

58 upvotes 6 months ago

A 42-year-old male has reached a plateau in hair regrowth after 8 months using Dutasteride, Minoxidil, a dermaroller, and Ketoconazole. Suggestions include continuing treatment, considering a hair transplant, and improving nutrition.

community 42 years old / 6 months / dut, minox, keto, dermaroller

46 upvotes 7 months ago

A 42-year-old is using dutasteride, oral and topical minoxidil, ketoconazole, and a dermaroller for hair loss, with noticeable progress after six months. They are questioning if further gains are possible and considering stopping the dermaroller, as advised that future improvements may only involve hair thickening.

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Experts

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