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Glossary 3D Skin Models

laboratory-engineered tissues that mimic human skin structure

3D Skin Models, also known as Three-Dimensional Skin Constructs or 3D Skin Equivalents, are laboratory-engineered tissues that mimic the structure and function of human skin. These models are created using layers of different cell types, such as keratinocytes and fibroblasts, to replicate the epidermis and dermis. They are used in research and testing to study skin biology, disease, and the effects of cosmetics or pharmaceuticals, providing a more accurate alternative to traditional 2D cell cultures and reducing the need for animal testing.

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Research

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research Improvement of Antioxidant Defences in Keratinocytes Grown in Physioxia: Comparison of 2D and 3D Models

9 citations , June 2023 in “Oxidative Medicine and Cellular Longevity”

This study reports that keratinocytes grown under low oxygen conditions (physioxia) demonstrated reduced reactive oxygen species production and increased antioxidant enzyme activity compared to those in higher oxygen conditions, highlighting the role of oxygen in regulating skin antioxidant defenses.

research Molecular Dermatology

January 2026 in “Methods in molecular biology”

The book provides updated methods for skin research and treatment.

research Type 2 Cytokine–Dependent Skin Barrier Regulation in Personalized 2-Dimensional and 3-Dimensional Skin Models of Atopic Dermatitis: A Pilot Study

2 citations , August 2024 in “JID Innovations”

This study suggests that keratinocytes derived from hair follicles of patients with atopic dermatitis provide a useful model for investigating AD-related inflammation, as they showed greater expression changes of AD markers when stimulated with type 2 cytokines compared to those from healthy donors.

research Spherical Skin Model: Stratified Co‐Culture of Fibroblasts and Keratinocytes on Spherical Beads Toward Compound Screening

December 2025 in “Advanced Healthcare Materials”

This study introduces a spherical skin model that effectively mimics key features of human skin, offering a scalable and rapid alternative for non-animal dermatological and cosmetic testing.

research Androgen Receptor Actions Modify Skin Structure and Chemical Carcinogen-induced Skin Cancer Susceptibility in Mice

14 citations , January 2015 in “Hormones and Cancer”

This study found that androgen receptor inactivation in male and female mice reduced susceptibility to DMBA-induced skin cancer, but the effect varied by the carcinogenesis model.

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Community Join

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community 11mth daily 0.5mg oral finasteride

in Finasteride/Dutasteride 835 upvotes 1 year ago

The user experienced significant hair regrowth with 0.5mg oral finasteride daily, despite a minoxidil allergy, and reported no side effects. They also used a keto shampoo and were satisfied with the results.

community Finasteride and Eye Problems: You’re Not Going Crazy

in Finasteride/Dutasteride 503 upvotes 1 year ago

Finasteride can cause dry eyes and vision issues due to its impact on the meibomian glands. Users have mixed experiences, with some experiencing eye discomfort and others having no side effects.

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Clinics

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Hair Loss TreatmentsDermatology
Asha Skin clinic n Laser center, Old Court Road Model Town Rewari, HaryanaRewari, Haryana · IN

Experts

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SMP Specialist
Noelle Skin
Nice, France

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Noelle Skin