Zinc-Dependent Factors in the Regulation of the Hair Follicle Cycle

January 2014 in “ Международный журнал прикладных и фундаментальных исследований ”

Т. В. Николаева, Н. П. Сетко, Л Г Воронина

zinc-dependent factors hair follicle cycle bazonuklin matrix metalloproteinases metallothionein anagen regulation apoptosis Bax survivin Bcl 2 family IAP family zinc concentration alopecia areata trace-element imbalances zinc hair growth cycle hair loss hair thinning

TLDR Zinc affects hair growth and may be linked to hair loss.

The article explored the role of zinc-dependent factors in regulating the hair follicle cycle, highlighting the involvement of bazonuklin, matrix metalloproteinases, and metallothionein in anagen regulation. It was noted that apoptosis in hair follicle cells was controlled by zinc-dependent proteins such as Bax and survivin from the Bcl 2 and IAP families. The study hypothesized that mineral imbalances affecting zinc concentration could contribute to the pathogenesis of alopecia areata, though experimental confirmation was needed to establish the impact of trace-element imbalances on the structural and functional condition of hair follicles.

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Zinc-Dependent Factors in the Regulation of the Hair Follicle Cycle

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