A Wirelessly Controlled Smart Bandage with 3D-Printed Miniaturized Needle Arrays

February 2020 in “ Advanced Functional Materials ”

Hossein Derakhshandeh, Fariba Aghabaglou, Alec McCarthy, Azadeh Mostafavi, Chris Wiseman, Zack Bonick, Ian Ghanavati, Seth Harris, Craig Kreikemeier‐Bower, Seyed Masoud Moosavi Basri, Jordan Rosenbohm, Ruiguo Yang, Pooria Mostafalu, Dennis P. Orgill, Ali Tamayol

vascular endothelial growth factor VEGF angiogenesis re-epithelialization chronic dermal wounds hair growth

TLDR The smart bandage improved healing in diabetic mice by delivering drugs directly into wounds.

The study developed a wirelessly controlled smart bandage with 3D-printed miniaturized needle arrays designed to deliver drugs directly into deeper layers of chronic wound beds. This programmable platform allowed for the active delivery of various drugs with independent temporal profiles, which was crucial for effective wound healing. The research demonstrated that delivering vascular endothelial growth factor (VEGF) using this method significantly improved wound closure, re-epithelialization, angiogenesis, and hair growth in chronic dermal wounds of diabetic mice compared to standard topical delivery methods. This highlighted the importance of both the choice of therapeutics and the delivery method in treating chronic wounds.

View this study on advanced.onlinelibrary.wiley.com →

Discuss this study in the Community →

Research cited in this study

1 / 1 results

research Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis

520 citations , February 2001 in “Journal of Clinical Investigation”

VEGF helps hair grow and determines follicle size by increasing blood vessel growth.

Similar Research

6 / 1000+ results

research Dermal-Epidermal Cross-Talk: Differential Interactions With Microvascular Endothelial Cells

6 citations , October 2016 in “Journal of Cellular Physiology”

Human dermal fibroblasts help microvascular endothelial cells grow, but not vice versa.

research The Dynamics of the Skin’s Immune System

306 citations , April 2019 in “International Journal of Molecular Sciences”

The skin has a complex immune system that is essential for protection and healing, requiring more research for better wound treatment.

research Dual Growth Factor Releasing Multi-Functional Nanofibers for Wound Healing

355 citations , August 2013 in “Acta Biomaterialia”

The nanofibers with two growth factors improved wound healing by supporting structure, preventing infection, and aiding tissue growth.

research An Overview of Growth Factors as the Potential Link Between Psoriasis and Metabolic Syndrome

6 citations , December 2023 in “Journal of Clinical Medicine”

Abnormal growth factor metabolism may link psoriasis and metabolic syndrome, and obesity can affect psoriasis treatment effectiveness.

research The Effect of Cilostazol, a Phosphodiesterase 3 (PDE3) Inhibitor, on Human Hair Growth with Dual Promoting Mechanisms

21 citations , April 2018 in “Journal of Dermatological Science”

Cilostazol helps hair grow by making hair root cells grow faster and changing growth factor levels.

research Ultraviolet Radiation in Wound Care: Sterilization and Stimulation

106 citations , July 2013 in “Advances in wound care”

UV radiation can help sterilize wounds and promote healing but requires careful use to avoid damaging cells.

A Wirelessly Controlled Smart Bandage with 3D-Printed Miniaturized Needle Arrays

Research cited in this study

research Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis

Related Community Posts Join

community Comprehensive Microneedling Guide

community New and Interesting HairLoss Studies/Papers/Reviews

community Anyone using oral castor oil in their stack?

community SAFFLOWER OIL good alternative for Minoxidil?

community What About Phytosterol Alternatives - Rice Bran Oil - Natural DHT Blockers

community The Korean began to suspect something. But they understood the mechanism to some extent. ( Cold shock therapy promotes hair growth in association with upregulation of cold-inducible RNA-binding protein and vascular endothelial growth factor)