TLDR The control system for hair growth cycles is not well understood and needs more research.
The document from August 1, 1999, discusses the limited understanding of the chronobiological control system that regulates the hair follicle cycling through its growth (anagen), regression (catagen), and resting (telogen) phases, despite over a century of research and recent advances in the molecular understanding of hair follicle morphogenesis. The author expresses surprise at the scarcity of theoretical concepts published on the control of hair follicle cycling, given the extensive literature on various aspects of hair growth control. The document emphasizes the importance of this question for both basic and clinical hair biology and calls for more systematic and serious exploration in this area.
Cited in this study
3 / 3 results
154 citations
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October 1996 in “Proceedings of the National Academy of Sciences of the United States of America” Estrogen affects hair growth and skin cell multiplication.
745 citations
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February 1992 in “Trends in genetics” Hair follicles create different cell layers and proteins, controlled by various molecules.
521 citations
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January 1954 in “Physiological Reviews” Hair growth is cyclic and influenced mainly by local factors.
April 2018 Some treatments like minoxidil, finasteride, and surgery can help with hereditary hair loss.
August 2014 in “Journal of clinical & experimental dermatology research” Platelet-released growth factors can treat hair loss by activating hair follicle stem cells, blocking certain pathways, and controlling inflammation and fibrosis.
24 citations
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November 2013 in “Trends in pharmacological sciences” Increasing ABC transporters in hair follicles may prevent chemotherapy-induced hair loss.
236 citations
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July 2001 in “Trends in Molecular Medicine” Future hair loss treatments should aim to extend hair growth, reactivate resting follicles, reverse shrinkage, and possibly create new follicles, with gene therapy showing promise.
370 citations
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September 1999 in “The New England Journal of Medicine” Finasteride and minoxidil are effective for hair loss, but continued research is needed for better treatments.
