Blockbuster Weight-Loss Drugs Not Tied to Suicidality, Studies Show

    May 2024 in “ Psychiatric News ”
    Linda M. Richmond
    Image of study
    TLDR Weight-loss drugs are not linked to suicidal thoughts.
    A review by the FDA found no evidence linking GLP-1 receptor agonists, a class of weight-loss and diabetes drugs, to suicidality. An independent large clinical trial with over 105,000 participants showed that those taking semaglutide were 27% less likely to experience initial suicidal ideation compared to those on non-GLP-1 obesity medications. The FDA continues to monitor for potential risks, including suicidal thoughts, aspiration, and alopecia. Psychiatrists are encouraged to play a more active role in managing obesity, especially in patients with serious mental illness, by incorporating holistic weight management plans and collaborating with specialists. Despite the benefits, high costs of these medications remain a significant barrier.
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