The Vitamin D Receptor, the Skin and Stem Cells

    February 2010 in “ The Journal of Steroid Biochemistry and Molecular Biology ”
    Hilary F Luderer, Marie B. Demay, Hilary F Luderer, Marie B. Demay
    Studysummary In this study, researchers observed that the absence of a functional vitamin D receptor in mice leads to impaired hair follicle regeneration due to defects in keratinocyte stem cells, resulting in alopecia.
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    Research cited in this study 16

    1. Vitamin D and Human Health: Lessons from Vitamin D Receptor Null Mice Endocrine reviews · 2008
    2. Vitamin D Receptor Is Essential For Normal Keratinocyte Stem Cell Function Proceedings of the National Academy of Sciences · 2007
    3. Hairless Triggers Reactivation of Hair Growth by Promoting Wnt Signaling Proceedings of the National Academy of Sciences of the United States of America · 2005
    4. Ligand-Independent Actions of the Vitamin D Receptor Maintain Hair Follicle Homeostasis Molecular Endocrinology · 2004
    5. Transient Activation of Beta-Catenin Signaling in Adult Mouse Epidermis Induces New Hair Follicles, Continuous Activation Maintains Tumors Development · 2004
    6. Enrichment for Living Murine Keratinocytes from the Hair Follicle Bulge with the Cell Surface Marker CD34 Journal of Investigative Dermatology · 2003
    7. Deletion of DNA Binding Domain of the Vitamin D Receptor Abrogates Genomic and Nongenomic Functions of Vitamin D Molecular Endocrinology · 2002
    8. Expression of ΔNLef1 in Mouse Epidermis Results in Differentiation of Hair Follicles into Squamous Epidermal Cysts and Formation of Skin Tumors Development · 2002
    9. Lack of the Vitamin D Receptor Is Associated with Reduced Epidermal Differentiation and Hair Follicle Growth ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2002
    10. Targeting Expression of the Human Vitamin D Receptor to the Keratinocytes of Vitamin D Receptor Null Mice Prevents Alopecia Endocrinology · 2001
    11. Targeting Expression of the Human Vitamin D Receptor to the Keratinocytes of Vitamin D Receptor Null Mice Prevents Alopecia Endocrinology · 2001
    12. Tcf3 and Lef1 Regulate Lineage Differentiation of Multipotent Stem Cells in Skin Genes & Development · 2001
    13. Metabolic And Cellular Analysis Of Alopecia In Vitamin D Receptor Knockout Mice Journal of Clinical Investigation · 2001
    14. Skin Abnormalities Generated by Temporally Controlled RXRα Mutations in Mouse Epidermis Nature · 2000
    15. Evaluation of Keratinocyte Proliferation and Differentiation in Vitamin D Receptor Knockout Mice Endocrinology · 2000
    16. Evaluation of Keratinocyte Proliferation and Differentiation in Vitamin D Receptor Knockout Mice Endocrinology · 2000

    Related research 7

    1. Morphogenesis, Growth Cycle, and Molecular Regulation of Hair Follicles Frontiers in Cell and Developmental Biology · 2022
    2. Dermal Papilla-Derived Wnt Ligands Are Required for Adult Hair Follicle Growth Journal of Investigative Dermatology · 2016
    3. Putting the Human Hair Follicle Cycle on the Map Journal of Investigative Dermatology · 2016
    4. Telogen Phase of Hair Growth Cycle Is Regulated by Cyclic Epithelial FGF18 Signaling Journal of Dermatological Science · 2012
    5. Hair Cycle Resting Phase Is Regulated by Cyclic Epithelial FGF18 Signaling Journal of Investigative Dermatology · 2012
    6. Towards a Molecular Understanding of Hair Loss and Its Treatment Trends in Molecular Medicine · 2001
    7. Expression of E6 and E7 Papillomavirus Oncogenes in the Outer Root Sheath of Hair Follicles Extends the Growth Phase and Bypasses Resting at Telogen PubMed · 2000