TLDR Vitamin D affects many body functions and its interaction with microRNAs could help treat related diseases.
Vitamin D plays a crucial role in various biological functions, including calcium and phosphate control, bone and hair formation and maintenance, immunomodulation, and proper barrier response. Deficiencies in vitamin D receptor signaling or vitamin D status can lead to clinical disorders such as osteomalacia, alopecia, increased cancer prevalence, and compromised immune and wound repair responses. MicroRNAs (miRNAs), small noncoding RNAs that regulate posttranscriptional networks, have been identified as significant mediators of vitamin D signaling. These miRNAs not only influence vitamin D signaling, but vitamin D also regulates miRNA networks during homeostasis and disease across species. The aim is to use this understanding of miRNAs for transformative clinical applications for vitamin D-regulated disorders and conditions.
10 citations,
May 2020 in “Frontiers in cell and developmental biology” MicroRNAs are important for hair growth regulation, with Dicer being crucial and Tarbp2 less significant.
68 citations,
December 2014 in “Cell Biochemistry and Function” Nuclear hormone receptors play a significant role in skin wound healing and could lead to better treatment methods.
1066 citations,
March 2010 in “Nature Reviews Molecular Cell Biology” MicroRNAs are crucial in controlling cell signaling, affecting cancer and tissue regeneration.
1533 citations,
October 2008 in “Endocrine reviews” Mice without the vitamin D receptor have bone issues and other health problems, suggesting vitamin D is important for preventing various diseases in humans.
119 citations,
July 2016 in “Annals of the New York Academy of Sciences” Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.
12 citations,
October 2021 in “Cells” Targeting a protein that blocks hair growth with microRNAs could lead to new hair loss treatments, but more research is needed.
11 citations,
October 2021 in “Frontiers in Cell and Developmental Biology” Non-coding RNAs are important for hair growth and could lead to new hair loss treatments, but more research is needed.
13 citations,
June 2020 in “BMC genomics” A specific microRNA, chi-miR-30b-5p, slows down the growth of hair-related cells by affecting the CaMKIIδ gene in cashmere goats.
10 citations,
May 2020 in “Frontiers in cell and developmental biology” MicroRNAs are important for hair growth regulation, with Dicer being crucial and Tarbp2 less significant.
