Vitamin D and MicroRNAs

Vitamin D plays a crucial role in various biological functions, including calcium and phosphate control, bone and hair formation and maintenance, immunomodulation, and proper barrier response. Deficiencies in vitamin D receptor signaling or vitamin D status can lead to clinical disorders such as osteomalacia, alopecia, increased cancer prevalence, and compromised immune and wound repair responses. MicroRNAs (miRNAs), small noncoding RNAs that regulate posttranscriptional networks, have been identified as significant mediators of vitamin D signaling. These miRNAs not only influence vitamin D signaling, but vitamin D also regulates miRNA networks during homeostasis and disease across species. The aim is to use this understanding of miRNAs for transformative clinical applications for vitamin D-regulated disorders and conditions.