The Mechanism by Which Dietary Vitamin A Regulates Skin Stem Cells During Hair Cycling

    January 2015 in “ OhioLink ETD Center (Ohio Library and Information Network) ”
    Liye Suo
    TLDR Balanced vitamin A is essential for healthy hair, as too much or too little can cause hair loss.
    This study investigated the role of dietary vitamin A in regulating skin stem cells during hair cycling, using samples from two mouse studies on alopecia areata and central centrifugal cicatricial alopecia. It was found that precise levels of vitamin A were crucial for hair health, as both deficiency and excess could lead to hair loss. High levels of vitamin A increased nuclear beta-catenin and WNT7A in hair follicle bulge cells, but also activated BMP signaling, which silenced WNT signaling and altered hair cycling. This effect could be reversed by reducing vitamin A intake. Additionally, proteins involved in retinoic acid synthesis and degradation were found to colocalize with stem cell markers during the telogen phase, with varying expression patterns.
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