Role of Vitamin D Receptor in Adult Hair Follicle Cycling

March 2006 in “ The FASEB Journal ”

Arnaud Edouard Teichert, Sandra M Chang, Hashem Elalieh, Daniel D Bikle

vitamin D receptor VDR hair follicle cycling anagen re-initiation transforming growth factor-beta receptor 2 noggin versican filaggrin keratin krt2–16

TLDR Vitamin D receptor is essential for adult hair growth.

The study investigated the role of the vitamin D receptor (VDR) in adult hair follicle cycling, revealing that the absence or alteration of VDR in both humans and mice led to a failure in adult hair follicle cycling, specifically affecting the re-initiation of the anagen phase. This disruption did not impact embryonic hair development, highlighting VDR's specific role in adult hair cycling. The research identified that VDR-deficient mouse hair follicles showed a lack of induction of key regulators like transforming growth factor-beta receptor 2 and noggin, decreased expression of versican, and changes in other markers, suggesting a disruption in the balance of cell proliferation and differentiation. This supported a model where VDR was crucial in regulating this balance in hair follicle cycling.

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community My Theory Regarding a Cause and Cure for Androgenetic Alopecia

in Treatment 97 upvotes 5 years ago

Hair loss theory suggests imbalance between Vitamin D Receptor (VDR) and Androgen Receptor (AR) activation. Proposed treatment includes upregulating VDR, downregulating AR, and improving mitochondrial health.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community Supplements for Health hair as for Gemini & Grok

in Chat 1 upvotes 2 weeks ago

The conversation discusses various supplements and vitamins like Vitamin D3, K2, Biotin, Iron, Zinc, and B Vitamins for improving hair health. It also mentions a combination of Tocotrienols, Pycnogenol, Saw Palmetto, Pumpkin Seed Oil, Stinging Nettle, and Myricetin for stabilizing hair, with Saw Palmetto, Pygeum, and Stinging Nettle noted for thickening hair despite side effects.

community Is Vitamin D the cause of my baldness or slow regrowth?

in Is this regrowth? 1 upvotes 1 month ago

The conversation discusses hair loss treatments, including oral finasteride, topical minoxidil, and microneedling, and the potential impact of Vitamin D and folic acid deficiencies on hair regrowth. It suggests that while male pattern baldness is the primary cause, addressing vitamin deficiencies may aid in improving regrowth.

community How a follicle next to it is so genetically different that it never miniaturized??

in Chat 219 upvotes 3 months ago

Genetic differences in hair follicles affect hair loss patterns. Treatments discussed include finasteride, dutasteride, minoxidil, and RU58841.

community Why are there no studies on Topical Vitamin D3 for AGA?

in Research/Science 10 upvotes 1 year ago

Topical Vitamin D3 may stimulate hair growth and has been used for Alopecia Areata. There is a question about the lack of research on its use for Androgenetic Alopecia (AGA).

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