TLDR PRC2 is not essential for hair follicle stem cell maintenance or hair growth.
The study investigated the role of Polycomb Repressive Complex 2 (PRC2) in hair follicle stem cells (HFSCs) and found that PRC2 played a non-instructive role in adult HFSCs. Using in vivo loss-of-function studies, researchers discovered that the absence of PRC2 did not affect HFSC quiescence or cell identity. Despite the upregulation of genes associated with the activated state of HFSCs in PRC2-null quiescent HFSCs, the transcriptional program regulated by PRC2 was found to be dispensable for maintaining HFSC quiescence and hair regeneration.
6 citations
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December 2021 in “PLoS Genetics” Polycomb Repressive Complex 2 is not needed for hair regeneration.
27 citations
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October 2021 in “Frontiers in Cell and Developmental Biology” There might be a specific histone code for cellular quiescence, but more research is needed.
7 citations
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January 2020 in “The journal of investigative dermatology/Journal of investigative dermatology” NIPP1 is important for healthy skin and could help treat skin inflammation.
76 citations
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July 2019 in “Cellular and Molecular Life Sciences” Stem cells are crucial for tissue growth, cancer treatment, and disease modeling, but challenges remain in clinical use.
September 2023 in “Animals” Genes linked to wool fineness in sheep have been identified.