An Update of Hair Shaft Disorders
October 1996
in “
Dermatologic clinics
”
hair shaft disorders congenital hair shaft abnormalities hereditary hair shaft abnormalities clinical characteristics microscopic characteristics topical selective gene therapy hair follicle faults molecular genetics clinical diagnostic criteria laboratory diagnostic criteria hair shaft anomalies increased fragility alopecia weathering process gene therapy hair follicle hair fragility hair loss
TLDR Advances in genetics may lead to targeted treatments for hair disorders.
The document provided an update on various hair shaft disorders, detailing their history, nomenclature, and characteristics. It discussed the concept of hair weathering due to cosmetic procedures and described specific conditions such as monilethrix, pseudomonilethrix, pili torti, Björnstad's syndrome, Menkes' kinky hair disease, Netherton's syndrome, and trichothiodystrophy. Each condition was elaborated with historical context, clinical features, and inheritance patterns. The document highlighted the importance of hair microscopy in diagnosing these disorders and noted the genetic and biochemical underpinnings of some conditions, such as the copper metabolism defect in Menkes' disease and the low sulfur content in trichothiodystrophy.
