Impact of Type 2 Cytokines on the Keratinocytes-Staphylococcus Aureus Interaction

    April 2023 in “ Journal of Investigative Dermatology ”
    F. Rademacher, H. Emmert, H. Norsgaard, O. Sørensen, M. Røpke, S. Gerdes, S. Weidinger, J. Harder
    Image of study
    TLDR Type 2 cytokines IL-4 and IL-13 increase skin's vulnerability to Staphylococcus aureus, which could be important for treating atopic dermatitis.
    The study investigates the interaction between type 2 cytokines IL-4 and IL-13, Staphylococcus aureus (SA), and keratinocytes derived from hair follicles in the context of atopic dermatitis (AD). The results show that SA alone increases the expression of AD-relevant markers and decreases keratinocyte differentiation markers. This effect is amplified when IL-4 and IL-13 are present. Furthermore, IL-4 and IL-13 stimulate the growth of extracellular SA, suggesting that these cytokines negatively affect the skin's defense against SA. This could be relevant to understanding and treating AD.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community Unofficial Dermapen/Roller Guide

      in Treatment  253 upvotes 5 years ago
      Treatments for hair loss, including microneedling (dermarolling and dermapen) and the use of minoxidil, finasteride, and RU58841. It provides detailed information about cost and usage of the various treatments, as well as potential side effects.

      community Comprehensive Microneedling Guide

      in Microneedling  295 upvotes 2 years ago
      Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.

      community Quit vaping/smoking = 80% less loss

      in Research/Science  235 upvotes 7 months ago
      Quitting vaping significantly reduced hair loss for a user who was a heavy vaper and also taking finasteride. Some participants suggest nicotine's vasoconstrictive properties may worsen hair loss, while others share personal anecdotes of hair improvement after quitting smoking or vaping.

    Similar Research

    5 / 1000+ results