Long-Term Effects of Trilostane in Dogs with Cushing's Syndrome
January 2011
TLDR Trilostane generally improved symptoms in dogs with Cushing's syndrome, but dosage adjustments were needed over time.
The study evaluated the long-term effects of trilostane in 33 dogs with Cushing's syndrome, focusing on treatment efficacy and adverse effects. Trilostane, a synthetic steroid, was generally well-tolerated, with most dogs showing improvement in symptoms such as polyuria/polydipsia and dermatological issues, including alopecia. However, some dogs experienced recurrent symptoms or required additional interventions. Adverse effects were mainly related to hypoadrenocorticism, with no significant drug interactions observed. Dosage adjustments were necessary over time, with a trend towards lower doses after 2 years. The study suggested that higher doses might be needed for treatments extending beyond 1.5 years, and further research was recommended to confirm these findings.