Tracking Research Trends and Hotspots in Sperm DNA Fragmentation Testing for the Evaluation of Male Infertility: A Scientometric Analysis

    December 2019 in “ Reproductive Biology and Endocrinology ”
    Saradha Baskaran, Ashok Agarwal, Manesh Kumar Panner Selvam, Renata Finelli, Kathy Amy Robert, Concetta Iovine, Peter Natesan Pushparaj, Luna Samanta, Avi Harlev, Ralf Henkel
    TLDR More research is needed to confirm sperm DNA fragmentation as a reliable tool for diagnosing male infertility.
    The document conducted a scientometric analysis of sperm DNA fragmentation (SDF) research from 1999 to 2018, revealing a significant increase in publications, particularly in the last decade, with 2,121 articles published over 20 years. The USA led in SDF research, with Agarwal A. as the most prolific author. Key research areas included lifestyle factors, asthenozoospermia, and varicocele, with oxidative stress being a major focus. Mechanistic studies on SDF were more common than prognostic/diagnostic studies, and the TUNEL technique was the most used for evaluating SDF. Despite the growing interest, routine SDF testing was not widely recommended, and more research was needed to establish SDF as a reliable prognostic/diagnostic tool in clinical and ART contexts.
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