Systemic Tofacitinib Treatment in Pediatric Patients with Resistant Alopecia Areata

January 2024 in “ Dermatologic therapy ”

Eda Öksüm Solak, Murat Borlu

tofacitinib Janus kinase inhibitor JAK inhibitor alopecia areata Severity of Alopecia Tool SALT score upper respiratory infection AA

TLDR Tofacitinib is a safe treatment for hair loss in children, but long-term use may be needed for best results.

The research article discusses a retrospective study on the use of systemic tofacitinib, a Janus kinase (JAK) inhibitor, for treating resistant alopecia areata (AA) in pediatric patients. The study involved 9 patients, average age 14.6 years, treated between 2019 and 2023. Results showed significant improvements in alopecia, especially at the 12-month mark, with 71.4% of the 7 patients who continued treatment for 12 months showing 50% or more improvement in Severity of Alopecia Tool (SALT) score. Only one patient reported an upper respiratory infection as a side effect. The study suggests that oral tofacitinib is a safe option for resistant pediatric AA patients, but long-term treatment might be necessary for optimal clinical response. The study's retrospective design and small patient cohort are significant limitations, and larger randomized studies are needed to further explore the efficacy and potential of JAK inhibitors in pediatric AA treatment.

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Research cited in this study

14 / 14 results

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Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

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in Research 865 upvotes 9 months ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community What else is good. Besides the big 3.

in Chat 35 upvotes 10 months ago

Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

community IGE Hair Loss and Miniaturization

in Chat 3 upvotes 4 months ago

A 23-year-old male is experiencing diffuse hair loss and miniaturization, possibly due to high IGE levels after using tofacitinib. He seeks advice and has not yet consulted a dermatologist.

community Topical solution recommendation

in Treatment 1 upvotes 2 weeks ago

The user is using finasteride 1mg every other day and seeks a topical solution excluding minoxidil. They are considering various combinations of ingredients like finasteride, dutasteride, and tofacitinib, with options for nourishing oils and other additives.

community Topical solution recommendation

in Product 1 upvotes 2 weeks ago

The user is using finasteride 1mg every other day and seeks a topical solution to complement it, excluding minoxidil. They are considering various combinations of ingredients like finasteride, dutasteride, and tofacitinib, with options for nourishing oils and other additives.

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Finasteride is available in Turkey without a prescription, with 1mg tablets costing 800 Turkish lira and 5mg tablets costing 150 lira. Oral minoxidil capsules were found at Cerrahpaşa nur eczanesi, also without a prescription.

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